LUNG ALERT: No difference in mortality between low and high PEEP

Bhatia, P.
October 2004
Thorax;Oct2004, Vol. 59 Issue 10, p842
Academic Journal
This article presents a study which reports that positive end expiratory pressure (PEEP) during ventilation improves arterial oxygenation by recruiting alveoli, but it may cause circulatory depression and increase airway pressure and lung volumes resulting in ventilator induced lung injury from overdistension. In acute lung injury and acute respiratory distress syndrome, mechanical ventilation is critical for the survival of the majority of patients. All patients received a tidal volume goal of 6 ml/kg predicted body weight and an inspiratory plateau pressure of 30 cm of water or less. Blood samples reflecting mechanisms of lung inflammation and injury. In this study, 549 patients with acute lung injury and were randomised to receive either high PEEP.


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