The electrochemistry and determination of Ligustrazine hydrochloride

Sun, Ziyi; Xiaofeng Zheng; Hoshi, Tomonori; Kashiwagi, Yoshitomo; Anzai, Jun-ichi; Genxi Li
October 2004
Analytical & Bioanalytical Chemistry;Oct2004, Vol. 380 Issue 3, p545
Academic Journal
Ligustrazine is one of the active ingredients contained inLigusticum chuanxiongHort. (Umbelliferae), which is widely used in traditional Chinese medicine for the treatment of cardiovascular problems. In this work, the electrochemistry of Ligustrazine hydrochloride (LZC) and its determination are investigated. The detection limit is estimated to be 8.0×10-8 M, with three linear ranges from 1.0×10-6 to 1.0×10-4 M, 1.0×10-4 to 5.0×10-4 M, and 6.5×10-4 to 1.6×10-3 M. The method has been proved to be highly sensitive, selective, and stable, and has been successfully applied to determining LZC in LZC injections.


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