Association of MHC Class I Related Gene B (MICB) to Celiac Disease

González, Segundo; Rodrigo, Luis; López-Vázquez, Antonio; Fuentes, Dolores; Agudo-Ibáñez, Lorena; Rodríguez-Rodero, Sandra; Fdez-Morera, Juan Luis; Martínez-Borra, Jesús; López-Larrea, Carlos
April 2004
American Journal of Gastroenterology;Apr2004, Vol. 99 Issue 4, p676
Academic Journal
BACKGROUND AND AIMS: Celiac disease (CD) is an enteropathic disorder characterized by strong association with HLA-DQ2. Our aim was to investigate whether MICB, a gene located in the MHC class I region, may contribute to CD susceptibility.PATIENTS AND METHODS: Total of 133 CD patients, previously reported to be associated with MICA-A5.1, and 116 controls were initially analyzed. Twenty-eight additional DQ2-negative CD patients were also studied. MICB was typed by PCR using sequence-specific primers. HLA-B, -DRB1, -DQA1, -DQB1, and MICA were also typed.RESULTS: The allele MICB0106 was strongly associated with CD (pc<0.000001, odds ratio (OR)= 5.6, 95% confidence interval (CI)= 3.1–10.1) and it was overrepresented in atypical patients compared with typical ones (pc= 0.04, OR= 2.9, CI= 1.4–6.1). MICB0106 was part of DR3-DQ2 haplotype (B8-MICA-A5.1-MICB0106-DR3-DQ2), and consequently a strong linkage disequilibrium between MICB0106 with DQ2 (λs= 1) and MICA-A5.1 (λs= 0.55) was found. To analyze whether the association of MICB is independent of this haplotype, its association was also studied in DQ2-negative patients (n= 46). DQ8 (28%vs9%, p= 0.0085,pc= NS) and MICB0104 (52%vs30%, p= 0.01,pc= NS) were increased in DQ2-negative patients. MICA-A5.1 was significantly increased in atypical patients (pc= 0.001, OR= 6.4, CI= 2.2–18.4), and this association was independent of DQ2 and DQ8 (pc= 0.02, OR= 2.6, CI= 1.1–6.1).CONCLUSIONS: The expression of MIC genes on enterocytes under stressful conditions and their function as ligands of intraepithelialγδ and CD8 T cells, together with the data presented here suggest a potential role of MIC genes in the pathogenesis of CD.


Related Articles

  • what's really causing your upset stomach.  // Shape;Sep2008, Vol. 28 Issue 1, p104 

    The author reports on celiac disease. The symptoms of celiac disease are mentioned, including bloating, chronic fatigue and joint pain. According to the article, a cure for celiac disease does not exist. Recommendations on the types of food which patients with celiac disease should eat are...

  • HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. Megiorni, Francesca; Pizzuti, Antonio // Journal of Biomedical Science;2012, Vol. 19 Issue 1, p88 

    Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the triggering environmental factor, the gluten, and the main genetic factors, Human...

  • Video Capsule Enteroscopy in the Diagnosis of Celiac Disease: A Multicenter Study. Rondonotti, Emanuele; Spada, Cristiano; Cave, David; Pennazio, Marco; Riccioni, Maria E.; de Vitis, Italo; Schneider, David; Sprujevnik, Tatiana; Villa, Federica; Langelier, Jennifer; Arrigoni, Arrigo; Costamagna, Guido; de Franchis, Roberto // American Journal of Gastroenterology;Aug2007, Vol. 102 Issue 8, p1624 

    OBJECTIVES: Duodenal biopsy is the current gold standard for diagnosis of celiac disease. Videocapsule endoscopy examines the entire small bowel and allows visualization of mucosal villi. We evaluated the potential of videocapsule endoscopy in assessing the severity and extent of mucosal changes...

  • Knowledge the participants have gained should bring a change in their practice - Wasim Jafri.  // Pulse International;5/31/2015, Vol. 16 Issue 10, p4 

    The article discusses the highlights of the Update on Gastrointestinal (GI) and Liver Disorders workshop organized on May 2, 2015 by the world Gastroenterology Organization in Karachi, Pakistan. It notes a presentation by Prof. Sadick Memon on the case of Non Cardiac Chest Pain caused by...

  • HLA-DQ and Susceptibility to Celiac Disease: Evidence for Gender Differences and Parent-of-Origin Effects. Megiorni, Francesca; Mora, Barbara; Bonamico, Margherita; Barbato, Maria; Montuori, Monica; Viola, Franca; Trabace, Simonetta; Mazzilli, Maria C. // American Journal of Gastroenterology;Apr2008, Vol. 103 Issue 4, p997 

    BACKGROUND AND AIMS: Celiac disease (CD) is twice as frequent among female than male. Despite the large number of reports on the DQ2/DQ8 association, no systematic studies have investigated a possible different role of the HLA genes in the two genders. We performed case-control and family-based...

  • Prevalence of celiac disease in adult patients with refractory functional dyspepsia: Value of routine duodenal biopsy. Giangreco, Emiliano; D'agate, Cinzia; Barbera, Carmelo; Puzzo, Lidia; Aprile, Giuseppe; Naso, Pietro; Bonanno, Giacomo; Russo, Francesco Paolo; Nicoletti, Alessandra; Incarbone, Salvatore; Trama, Giuseppe; Russo, Antonio // World Journal of Gastroenterology;12/7/2008, Vol. 14 Issue 45, p6948 

    Aim: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gastroenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia. METHODS: Seven hundred and twenty six...

  • Celiac Disease: The Great Pretender. Underwood, Anne // Saturday Evening Post;Mar/Apr2010, Vol. 282 Issue 2, p44 

    The article discusses celiac disease. In addition to intestinal distress, sufferers may develop additional maladies including osteoporosis and anemia. Some data suggest that an inability to tolerate gluten that characterizes celiac disease is increasing. One theory for the disease posits that...

  • MACROLIPASEMIA AND CELIAC DISEASE. Garcia-Gonzalez, Miguel; Defarges-Pons, Victor; Monescillo, Alberto; Hernandez, Felix; Cano-Ruiz, Ana // American Journal of Gastroenterology;Dec1995, Vol. 90 Issue 12, p2233 

    A case of undiagnosed celiac disease associated with macrolipasemia and macroamylasemia is reported. This association is almost unique. To our knowledge, only one case has been previously diagnosed. Previous case reports about macroamylasemia and celiac disease, as well as macrolipasemia, are...

  • Longitudinal Study on the Effect of Treatment on Body Composition and Anthropometry of Celiac Disease Patients. Smecuol, Edgardo; Gonzalez, Diana; Mautalen, Carlos; Siccardi, Ana; Cataldi, Monica; Niveloni, Sonia; Mazure, Roberto; Vazquez, Horacio; Pedreira, Silvia; Soifer, Graciela; Boerr, Luis A.; Mauriño, Eduardo; Bai, Julio C. // American Journal of Gastroenterology;Apr1997, Vol. 92 Issue 4, p639 

    Objectives: This prospective study was designed to assess the nutritional changes associated with the long-term treatment of celiac disease. In addition, we analyzed whether these changes were related to the degree of compliance with a gluten-free diet. Methods: We studied nutritional parameters...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics