Anorectal Dysfunction Increases with Time Following Radiation Therapy for Carcinoma of the Prostate

Yeoh, Eric E. K.; Holloway, Richard H.; Fraser, Robert J.; Botten, Rochelle J.; Di Matteo, Addolorata C.; Moore, James W. E.; Schoeman, Mark N.; Bartholomeusz, F. Dylan L.
February 2004
American Journal of Gastroenterology;Feb2004, Vol. 99 Issue 2, p361
Academic Journal
OBJECTIVES: To characterize the prevalence and pathophysiology of anorectal dysfunction up to 2 yr following radiation therapy (RT) for localized carcinoma of the prostate.METHODS: Thirty-eight patients, median age 68 (range 60–82) yr with localized prostate carcinoma randomly assigned to one of two radiation dose schedules, underwent evaluation of the following variables of anorectal function before RT, as well as 4–6 wk and 1 and 2 yr after its completion: (1) symptoms, (2) anorectal motility, (3) anorectal sensory function, and (4) anal sphincteric morphology.RESULTS: There was a persistent increase in anorectal symptoms after RT. At 2 yr, bowel frequency, urgency, and fecal incontinence were increased in 50%, 47%, and 26% of patients, respectively. After RT, there were progressive reductions of (1) basal anal pressures, (2) anal pressures in response to squeeze and increased intra-abdominal pressure, (3) rectal compliance, and (4) rectal volumes associated with sensory perception and the desire to defecate. The thickness of the external anal sphincter increased with time after RT. No difference was observed between the patients in the two radiation dose schedules.Anorectal dysfunction following RT for prostate carcinoma is an underestimated cause of morbidity, which progresses with time. The prevalence and pathophysiology of anorectal dysfunction is similar after treatment with two commonly used radiation dose schedules.


Related Articles

  • Can Anorectal Manometry Findings Predict Subsequent Late Gastrointestinal Radiation Toxicity in Prostate Cancer Patients? Yunseon Choi; Won Park; Poong-Lyul Rhee // Cancer Research & Treatment;2016, Vol. 48 Issue 1, p297 

    Purpose The purpose of this study is to investigate the influence of radiotherapy (RT) on anorectal function and radiation-induced toxicity in patients with prostate cancer. Materials and Methods Fifty-four patients who were treated with RT for prostate cancer (T1c-4N0-1M0) were evaluated. To...

  • Digital rectal exams' effect on PSA values not clinically important.  // Geriatrics;May95, Vol. 50 Issue 5, p66 

    Presents an abstract of the article `Effect of digital rectal examination on serum prostate-specific antigen in a primary care setting,' originally published in the `Archives of Internal Medicine' journal.

  • Annual exams aid in detection, treatment of prostate cancer. Echt // Business Press;08/20/99, Vol. 12 Issue 17, p10A 

    Focuses on the best way of beating prostate cancer. Advantages of having an annual digital rectal exam and a prostate specific antigen blood test; Designation of September as National Prostate Cancer Awareness Month in the United States; Risks to surgical removal of prostate gland; Variety of...

  • Anorectal and perineal pain: new pathophysiological hypothesis. Mazza, L.; Formento, E.; Fronda, G. // Techniques in Coloproctology;Aug2004, Vol. 8 Issue 2, p77 

    Anorectal and perineal pain has been described in association with a variety of organic conditions but can also occur under circumstances in which organic disorders are absent and pathophysiology is uncertain. The three most common functional disorders causing anorectal and perineal pain are...

  • Pathophysiology and Role of Biofeedback Therapy in Solitary Rectal Ulcer Syndrome. Rao, Satish S. C.; Ozturk, Ramazan; De Ocampo, Sherrie; Stessman, Mary // American Journal of Gastroenterology;Mar2006, Vol. 101 Issue 3, p613 

    BACKGROUND: Solitary rectal ulcer syndrome (SRUS) is a behavioral disorder whose pathophysiology is incompletely understood. Likewise, its treatment, particularly the role of biofeedback therapy (BT) is unclear. AIM: To evaluate anorectal function and morphology and to assess efficacy of BT....

  • UNDERSTANDING THE PATHOPHYSIOLOGY OF DYSPHAGIA AND CONSTIPATION IN NEUROLOGIC DISORDERS. Wald, Arnold // American Journal of Gastroenterology;Jan1994, Vol. 89 Issue 1, p1 

    Examines the pathogenesis of functional dysphagia and constipation in neurologic disorders. Initial phases of dysphagia; Technique used to study the oropharynx and esophagus; Identification of primary anorectal abnormalities.

  • Current perspectives in the treatment of advanced prostate cancer. Victor Valdespino; Panagiotis Tsagozis; Pavel Pisa // Medical Oncology;Sep2007, Vol. 24 Issue 3, p273 

    Abstract  Prostate cancer (PC) continues to be an important world health problem for men. Patients with locally confined PC are treated with either radiotherapy or surgery. However, treatment of more advanced stages of the disease is problematic. Initially, androgen deprivation offers a...

  • Optimizing local control in anorectal melanoma. Ramakrishnan, A. S.; Mahajan, V.; Kannan, R. // Indian Journal of Cancer;Jan-Mar2008, Vol. 45 Issue 1, p13 

    BACKGROUND: Wide local excision (WLE) of anorectal melanoma is associated with a high incidence of local recurrence. There is a paucity of literature on adjuvant radiation in this malignancy. AIM: To identify the optimal method of local treatment in anorectal melanoma. SETTINGS AND DESIGN:...

  • Single-arc volumetric-modulated arc therapy can provide dose distributions equivalent to fixed-beam intensity-modulated radiation therapy for prostatic irradiation with seminal vesicle and/or lymph node involvement. Fontenot, J. D.; King, M. L.; Johnson, S. A.; Wood, C. G.; Price, M. J.; Lo, K. K. // British Journal of Radiology;Mar2012, Vol. 85 Issue 1011, p231 

    Objectives: Volumetric-modulated arc therapy (VMAT) is becoming an increasingly utilised modality for treating a variety of anatomical sites. However, the efficacy of single-arc VMAT to treat prostate cancer suspicious for extraprostatic extension was heretofore unknown. In this work, we report...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics