TITLE

Pancreatic Mass Lesions Associated with Raised Concentration of IgG4

AUTHOR(S)
Hirano, Kenji; Komatsu, Yutaka; Yamamoto, Natsuyo; Nakai, Yousuke; Sasahira, Naoki; Toda, Nobuo; Isayama, Hiroyuki; Tada, Minoru; Kawabe, Takao; Omata, Masao
PUB. DATE
October 2004
SOURCE
American Journal of Gastroenterology;Oct2004, Vol. 99 Issue 10, p2038
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Autoimmune pancreatitis (AIP) is a recognized benign disease characterized by irregular narrowing of the pancreatic duct, swelling of parenchyma, lymphoplasmacytic infiltration and fibrosis, and a favorable response to corticosteroid treatment. In this condition, the whole pancreas is diffusely affected. Recently, however, a few cases with locally affected lesions were reported, with some of them showing features similar to cancer. We reviewed 138 patients with pancreatic mass lesion, of which 17 were not initially diagnosed despite examinations. Serum IgG4 levels were elevated in seven of them. Their biopsy specimens had a similar appearance to those of AIP. We considered that they should be diagnosed as AIP or conditions related to AIP. Among the 10 patients without elevated IgG4, 4 patients were diagnosed as pancreatic cancer after follow-up, 1 presented with an islet cell tumor, 1 presented AIP with sclerosing cholangitis, and the other 4 had chronic pancreatitis.
ACCESSION #
14816490

 

Related Articles

  • Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis. Hamano, Hideaki; Arakura, Norikazu; Muraki, Takashi; Ozaki, Yayoi; Kiyosawa, Kendo; Kawa, Shigeyuki // Journal of Gastroenterology;Dec2006, Vol. 41 Issue 12, p1197 

    Autoimmune pancreatitis is a unique form of chronic pancreatitis characterized by high serum IgG4 concentrations and abundant IgG4-bearing plasma cell infiltration in the pancreatic lesion, and it has been reported to be associated with a variety of extrapancreatic lesions, leading us to...

  • Misdiagnosis of Autoimmune Pancreatitis: A Caution to Clinicians. Gardner, Timothy B.; Levy, Michael J.; Takahashi, Naoki; Smyrk, Thomas C.; Chari, Suresh T. // American Journal of Gastroenterology;Jul2009, Vol. 104 Issue 7, p1620 

    Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas that is increasingly encountered worldwide. It has generated considerable interest, in part because the inflammatory process usually responds dramatically to corticosteroid therapy. The most common presentation...

  • Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal. Okazaki, Kazuichi; Kawa, Shigeyuki; Kamisawa, Terumi; Naruse, Satoru; Tanaka, Shigeki; Nishimori, Isao; Ohara, Hirotaka; Ito, Tetsuhide; Kiriyama, Seiki; Inui, Kazuro; Shimosegawa, Tooru; Koizumi, Masaru; Suda, Koichi; Shiratori, Keiko; Yamaguchi, Koji; Yamaguchi, Taketo; Sugiyama, Masanori; Otsuki, Makoto // Journal of Gastroenterology;Jul2006, Vol. 41 Issue 7, p626 

    The article discusses the proposed amendments for clinical diagnostic criteria of autoimmune pancreatitis (AIP) by the Research Committee of Intractable Diseases of the Pancreas. The extrapancreatic lesions that may be associated with AIP include biliary lesions, sialadenitis, retroperitoneal...

  • Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease. Kamisawa, Terumi; Okamoto, Atsutake // Journal of Gastroenterology;Jul2006, Vol. 41 Issue 7, p613 

    Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis of presumed autoimmune etiology. Many new clinical aspects of AIP have been clarified during the past 10 years, and AIP has become a distinct entity recognized worldwide. However, its precise pathogenesis or pathophysiology remains...

  • Is it time to reconsider autoimmune pancreatitis? Kamisawa, Terumi // Journal of Gastroenterology;Dec2006, Vol. 41 Issue 12, p1240 

    The author reflects on the study about autoimmune pancreatitis (AIP). The characteristic features of AIP including its association with various extrapancreatic lesions are mentioned, as well the five major extrapancreatic lesions. The author agrees with the proposed systemic entity of...

  • Recent Patents on the Treatment of Type 1 Diabetes. Fierabracci, Alessandra // Recent Patents on Endocrine, Metabolic & Immune Drug Discovery;Jan2009, Vol. 3 Issue 1, p1 

    The incidence of endocrine autoimmunity is increasing worldwide. Complex molecular and cellular mechanisms underline the pathogenesis of autoimmune diseases with the contribution of putative environmental factors and the requisite allele(s) responsible for antigen presentation by...

  • Specificity of Serum Amylase and Amylase Creatinine Clearance Ratio in the Diagnosis of Acute and Chronic Pancreatitis. Grosberg, Saul J.; Wapnick, Simon; Purow, Elias; Purow, Joan R. // American Journal of Gastroenterology;Jul1979, Vol. 72 Issue 1, p41 

    In 31 patients with pancreatitis, the amylase to creatinine clearance ratio (CACR) was significantly greater than for controls (10.7 ± 1.7 vs. 2.6 ± 0.3, P < .001). Sixteen pancreatitis patients with serum amylase (SAm) within the normal range had a mean CACR significantly greater than...

  • Significance of Angiography of the Pancreas in the Diagnosis of Chronic Pancreatitis. Orlov, V. A. // American Journal of Gastroenterology;Nov1977, Vol. 68 Issue 5, p461 

    The author made angiographic studies of pancreas in 94 patients with chronic pancreatitis. In all patients there were alterations in angiographic architecture of the pancreas. Ten angiogaphic signs were described which in combinations of three or more, were deemed sufficient for diagnosis of...

  • Clinical Application of Amylase Isoenzyme Analysis. Berk, J. Edward; Fridhandler, Louis // American Journal of Gastroenterology;Jun1975, Vol. 63 Issue 6, p457 

    Describes the clinical application of amylase isoenzyme analysis in the identification of pancreatic disease. Detection and separation of amylase isoenzymes; Relative distributions of isoamylases in normal serum and in serum of patients with acute pancreatitis; Normal serum amylase values.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics