Significance of HBV DNA Levels in Liver Histology of HBeAg and Anti-HBe Positive Patients with Chronic Hepatitis B

Man-Fung Yuen; Irene Oi-Lin Ng; Sheung-Tat Fan; He-Jun Yuan; Danny Ka-Ho Wong; John Chi-Hang Yuen; Simon Siu-Man Sum; Annie On-On Chan; Ching-Lung Lai
October 2004
American Journal of Gastroenterology;Oct2004, Vol. 99 Issue 10, p2032
Academic Journal
OBJECTIVE: To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores.PATIENTS AND METHODS: Liver histology and HBV DNA levels were determined in 94 patients with chronic hepatitis B.RESULTS: There was no association between HBV DNA levels and liver histology in hepatitis-B-e antigen-positive patients (n= 43). In anti-HBe-positive patients (n= 51), HBV DNA levels correlated positively with HAI-NI (r= 0.31,p= 0.014) and HAI-F (r= 0.33,p= 0.017) scores. Though the majority of anti-HBe-positive patients with HBV DNA levels<105 copies/ml had mild necroinflammation and no fibrosis, 14.3% had established fibrosis. Anti-HBe-positive patients with core promoter mutations had a poorer histology compared to those without. There was no difference in the histology between anti-HBe-positive patients with and without precore mutations. Alanine aminotransferase (ALT) level correlated positively with HAI-NI score. Patients with persistently normal ALT levels had a significantly lower median HAI-NI score compared to patients with either persistently or intermittently elevated ALT levels.CONCLUSIONS: In anti-HBe-positive patients, though HBV DNA level<105 copies/ml was associated with better histology, 14.3% patients had established fibrosis. Further studies to define a better cut-off HBV DNA level to differentiate low- and high-risk patients for disease progression are required.


Related Articles

  • Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen—Positive Chronic Hepatitis B. Marcellin, Patrick; Chang, Ting-Tsung; Lim, Seng Gee; Tong, Myron J.; Sievert, William; Shiffman, Mitchell L.; Jeffers, Lennox; Goodman, Zachary; Wulfsohn, Michael S.; Xiong, Shelly; Fry, John; Brosgart, Carol L. // New England Journal of Medicine;2/27/2003, Vol. 348 Issue 9, p808 

    Background: In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains. Methods: We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to...

  • Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen—Negative Chronic Hepatitis B. Hadziyannis, Stephanos J.; Tassopoulos, Nicolaos C.; Heathcote, E. Jenny; Chang, Ting-Tsung; Kitis, George; Rizzetto, Mario; Marcellin, Patrick; Lim, Seng Gee; Goodman, Zachary; Wulfsohn, Michael S.; Xiong, Shelly; Fry, John; Brosgart, Carol L. // New England Journal of Medicine;2/27/2003, Vol. 348 Issue 9, p800 

    Background: Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials. Methods: We randomly assigned 185 patients with chronic hepatitis B who were negative for hepatitis B e antigen...

  • Liver Histology and HBV DNA Levels in Chronically HBV Infected Patients with Persistently Normal Alanine Aminotransferase. Montazeri, Ghodrate; Rahban, Maryam; Mohamadnejad, Mehdi; Zamani, Farhad; Hooshyar, Afshin; Fazlolahi, Atoosa; Abedian, Shifteh; Ghoujeghi, Farhad; Estakhri, Arezoo; Montazeri, Farhad; Razjoyan, Hadi; Mamarabadi, Mansoureh; Alimohamadi, Meysam; Tavangar, Seyed Mohamad; Malekzadeh, Reza // Archives of Iranian Medicine (AIM);May2010, Vol. 13 Issue 3, p193 

    Background: Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients. Methods: There were 132 patients with...

  • Factors associated with spontaneous HBsAg clearance in chronic hepatitis B patients followed at a university hospital. Ferreira, Sandro C.; Chachá, Silvana G. F.; Souza, Fernanda F.; Teixeira, Andreza C.; Santana, Rodrigo C.; Villanova, Márcia G.; Zucoloto, Sérgio; Ramalho, Leandra N.; Perdoná, Gleici S. C.; Passos, Afonso D. C.; Martinelli, Ana L. C. // Annals of Hepatology: Official Journal of the Mexican Associatio;Nov/Dec2014, Vol. 13 Issue 6, p762 

    Introduction. Few studies have evaluated the factors involved in the spontaneous HBsAg seroclearance in patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas with a low prevalence of HBV infection. We aimed to determine the rate of spontaneous HBsAg seroclearance...

  • Molecular biology of hepatitis B virus: effect of nucleotide substitutions on the clinical features of chronic hepatitis B. Yokosuka, Osamu; Arai, Makoto // Medical Molecular Morphology;Sep2006, Vol. 39 Issue 3, p113 

    Hepatitis B virus (HBV) is a major cause of liver disease worldwide. It is covered with envelope (surface antigen) proteins with the nucleocapsid (core antigen) inside. In the nucleocapsid, there is an incomplete double-stranded DNA and a DNA polymerase. Four genes, S, C, X, and P, are encoded,...

  • Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-Year prospective study.  // Virology Journal;2011, Vol. 8 Issue 1, p444 

    The article offers information on the study conducted by the authors related to the optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment hepatitis B virus (HBV) DNA. It states that adefovir dipivoxil (ADV) is an important agent to suppress HBV...

  • Causes of academic failure of medical and medical sciences students in Iran: a systematic review. Azari, Sheida; Baradaran, Hamid Reza; Fata, Ladan // Medical Journal of the Islamic Republic of Iran;2015, Vol. 29, p1 

    Background: Academic failure of medical and medical sciences students is one of the major problems of higher education centers in many countries. This study aims to collect and compare relevant researches in this field in Iran. Methods: The appropriate keywords were searched in the national and...

  • Hepatology.  // Current Medical Literature: Gastroenterology;2008, Vol. 27 Issue 2, p48 

    The article presents abstracts on hepatology which include "Hepatitis B Virus DNA Levels at Week 4 of Lamivudine Treatment Predict the 5-year Ideal Response," "Incidence and Natural Course of Fatty Liver in the General Population: The Dionysos study" and "A Large-Scale, Multicentre, Double-blind...

  • Decreased Diversity of the Oral Microbiota of Patients with Hepatitis B Virus-Induced Chronic Liver Disease: A Pilot Project. Ling, Zongxin; Liu, Xia; Cheng, Yiwen; Jiang, Xiawei; Jiang, Haiyin; Wang, Yuezhu; Li, Lanjuan // Scientific Reports;11/27/2015, p17098 

    Increasing evidence suggests that altered gut microbiota is implicated in the pathogenesis of hepatitis B virus-induced chronic liver disease (HBV-CLD). However, the structure and composition of the oral microbiota of patients with HBV-CLD remains unclear. High-throughput pyrosequencing showed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics