Isolated Visceral Small Artery Fibromuscular Hyperplasia-Induced Ischemic Colitis Mimicking Inflammatory Bowel Disease

Gan, Sen Ian; Urbanski, Stefan; Coderre, Sylvain P.; Panaccione, Remo
October 2004
American Journal of Gastroenterology;Oct2004, Vol. 99 Issue 10, p2058
Academic Journal
A unique case of fibromuscular hyperplasia (FMH) of the visceral vasculature is presented. A 31-yr-old patient presented with a chronic colitis initially diagnosed as ulcerative colitis 1 yr earlier. On presentation, the endoscopic appearance showed deep linear ulcerations and cobblestoning and was more consistent with Crohn's disease. Biopsies of the area, however, suggested an ischemic etiology. The patient failed to respond to local 5ASA and prednisone therapy and progression of the disease led to a left hemicolectomy. A diagnosis of a small vessel fibromuscular arteriopathy was made on the resected specimen. This is the first case presentation of FMH mimicking inflammatory bowel disease. The lack of any systemic involvement of FMH with isolated small vessel disease has never been reported and serves as an index case of which clinicians should be aware. The literature is reviewed and the possible implications are discussed.


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