Rhabdomyolysis After Penetrating Trauma

Brown, Carlos V. R.; Rhee, Peter; Evans, Kelly; Demetriades, Demetrios; Velmahos, George
October 2004
American Surgeon;Oct2004, Vol. 70 Issue 10, p890
Academic Journal
Rhabdomyolysis (RHAB) is a known complication following blunt trauma. RHAB after penetrating trauma has not been studied. The objective of this study was to evaluate the incidence, risk factors, and complications of RHAB following penetrating trauma. Over a 5-year period, penetrating trauma patients admitted to our intensive care unit (ICU) were studied. Significant RHAB was defined as a CK level of 5000 U/L or higher. There were 873 patients (29 ± 12 years old, 92% male), of whom 767 (88%) bad abnormal CK levels (range 520-165,943 U/L), and 111 patients (13%) developed significant RHAB. Victims of penetrating trauma who sustain vascular and severe extremity injury are at a sixfold increased risk to develop significant RHAB. Patients with significant RHAB had a higher rate of renal failure (23% vs 7%, P < 0.0001) and longer ICU stay (15 ± 26 days us 8 ± 12 days, P < 0.0001). CK elevations and significant RHAB are common after penetrating trauma. Patients who sustain vascular and severe extremity injury as a result of their penetrating wounds are at high risk to develop significant RHAB, resulting in renal failure and prolonged ICU stay. Therefore, critically injured penetrating trauma patients should be routinely screened with CK levels.


Related Articles

  • Phendimetrazine.  // Reactions Weekly;5/6/2006, Issue 1100, p18 

    Presents the study "Rare Case of Rhabdomyolisis With Therapeutic Doses of Phendimetrazine Tartrate," which appeared in the January 2006 issue of the "Journal of Investigative Medicine." Background on the patient.

  • Simvastatin.  // Reactions Weekly;5/21/2011, Issue 1352, p33 

    The article describes the case of a 74-year-old woman who developed rhabdomyolysis while taking simvastatin.

  • Rhabdomyolysis.  // Encyclopedic Reference of Molecular Pharmacology;2004, p826 

    A definition of the term "rhabdomyolysis" is presented which refers to the disintegration and death of muscle cells.

  • Rhabdomyolysis. Sauret, John M.; Marinides, George; Wang, Gordon K. // American Family Physician;3/1/2002, Vol. 65 Issue 5, p907 

    Rhabdomyolysis is a potentially life-threatening syndrome resulting from the break down of skeletal muscle fibers with leakage of muscle contents into the circulation. The most common causes are crush injury, over exertion, alcohol abuse and certain medicines and toxic substances. Several...

  • Role of Elevated Aminotransferases in ICU Patients with Rhabdomyolysis. RAURICH, JOAN M.; LLOMPART-POU, JUAN A.; RODRIGUEZ-YAGO, MIGUEL; FERRERUELA, MIREIA; ROYO, CRISTINA; AYESTARAN, IGNACIO; Rodríguez-Yago, Miguel; Ayestarán, Ignacio // American Surgeon;Dec2015, Vol. 81 Issue 12, p1209 

    To evaluate whether patients with rhabdomyolysis and serum alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) higher than 1000 IU/L had higher mortality that patients with low aminotransferases. Retrospective analysis of intensive care unit patients with rhabdomyolysis...

  • Prevalence and demographic characteristics of exertional rhabdomyolysis in horses in Australia. Cole, F.L.; Mellor, D.J.; Hodgson, D.R.; Reid, S.W.J. // Veterinary Record: Journal of the British Veterinary Association;11/13/2004, Vol. 155 Issue 20, p625 

    The proportion of the horses, of both sexes and of different ages, breeds and levels of activity, owned by a stratified random sample of Australian owners, which had suffered one or more episodes of exertional rhabdomyolysis during the previous 12 months was determined. The proportion in the...

  • Unmasking of Carnitine Palmitoyltransferase Deficiency during an Acute Exacerbation of Asthma Complicated by Rhabdomyolysis in a Soldier. Gilad, Jacob; Pirogovsky, Avinoam; Bartal, Carmi // Military Medicine;Oct2004, Vol. 169 Issue 10, p821 

    Rhabdomyolysis is a life-threatening condition that may result from various etiologies. We report a rare case of severe rhabdomyosis in a soldier after a mild acute asthma exacerbation. Further work-up revealed an underlying deficiency of type II carnitine palmitoyltransferase. The case is...

  • Gatifloxacin-induced rhabdomyolysis. George, P.; Das, J.; Pawar, B.; Badyal, D. // Journal of Postgraduate Medicine;Jul-Sep2008, Vol. 54 Issue 3, p233 

    The article presents the case study of a 50-year-old male who was admitted with intermittent fever and lower urinary tract symptoms for two days. No oliguria or dark urine was noticed. No alcohol abuse, illicit drugs, unprescribed medication use, unaccustomed exercise or trauma was present. In...

  • Incidence and risk factors associated with exertional rhabdomyolysis syndrome in National Hunt racehorses in Great Britain. Upjohn, M. M.; Archer, R. M.; Christley, R. M.; McGowan, C. M. // Veterinary Record: Journal of the British Veterinary Association;6/11/2005, Vol. 156 Issue 24, p763 

    A telephone survey 51 National Hunt racing yards with 1140 horses is training was made in April and May 2003 to establish incidence of exertional rhabdomyolysis syndrome during the previous year. A case-control study was used to investigate the risk factors for the syndrome in eight yards...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics