Linezolid Therapy for Orthopedic Infections

Razonable, Raymund R.; Osmon, Douglas R.; Steckelberg, James M .
September 2004
Mayo Clinic Proceedings;Sep2004, Vol. 79 Issue 9, p1137
Academic Journal
The article discusses linezolid therapy for orthopedic infections. Studies show that linezolid is effective for the treatment of orthopedic infections due to grain-positive cocci in combination with surgical debridement and removal of infected hardware or bone. Linezolid may be an effective alternative antimicrobial treatment for selected patients who are unable to tolerate other antimicrobial drugs or who are infected with strains of bacteria resistant to other antimicrobial agents. Although oral linezolid treatment is convenient and effective, careful monitoring of potential adverse events, especially hematologic and neuropathic toxicities, is warranted with long-term linezolid use.


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