TITLE

Enhanced vascular responses to noradrenaline in isolated omental arteries from patients with advanced cirrhosis: evidence against intrinsic vascular hyporeactivity in cirrhosis

AUTHOR(S)
Vaughan, R. B.; Angus, P. W.; Angus, J. A.
PUB. DATE
October 2004
SOURCE
Gut;Oct2004, Vol. 53 Issue 10, p1544
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article reports that the mesenteric and systemic vasodilatation that occurs in advanced liver disease leads to the development of a hyperdynamic circulatory state, which in turn underlies many of the complications of cirrhosis. Studies of isolated vessel preparations from cirrhotic animal models have led to the concept that vasodilatation is linked to an intrinsic vascular hyporesponsiveness to endogenous vasoconstrictors such as noradrenaline, but whether the same holds true of human blood vessels in cirrhosis has not been established. A hyperdynamic circulation was confirmed by invasive measurement of haemodynamic parameters prior to surgery. This study is the first of its kind to directly address the question of whether intrinsic hyporeactivity to endogenous vasopressors is present in small resistance arteries from patients with cirrhosis.
ACCESSION #
14674407

 

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