Antibiotic use and the development of Crohn's disease: methodological issues

Schneider, V.; Suissa, S.
October 2004
Gut;Oct2004, Vol. 53 Issue 10, p1544
Academic Journal
This article reports that the use of antibiotics could increase the risk of Crohn's disease, particularly those prescribed 2-5 years prior to the diagnosis. As the use of drugs acting on the central nervous system and of other prescription drugs such as oral contraceptives was also associated with a diagnosis of Crohn's disease, the authors concluded that this association is non-specific. One methodological aspect of the study design that could have biased the findings is that calendar time was not accounted for properly. This is highlighted by the fact that the median time available prior to the index date, the period during which exposure to antibiotics was measured, was 6.4 years for the cases compared with 8.2 years for the controls.


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