TITLE

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis

AUTHOR(S)
Frazer, D. M.; Inglis, H. R.; Wilkins, S. J.; Millard, K. N.; Steele, T. M.; McLaren, G. D.; Mckie, A. T.; Vulpe, C. D.; Anderson, G. J.
PUB. DATE
October 2004
SOURCE
Gut;Oct2004, Vol. 53 Issue 10, p1509
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: The delay of several days between an erythropoietic stimulus and the subsequent increase in intestinal iron absorption is commonly believed to represent the time required for body signals to programme the immature crypt enterocytes and for these cells to migrate to the villus. Recent data however suggest that signals from the body to alter absorption are mediated by circulating hepcidin and that this peptide exerts its effect on mature villus enterocytes. Methods: We have examined the delay in the absorptive response following stimulated erythropoiesis using phenylhydrazine induced haemolysis and correlated this with expression of hepcidin in the liver and iron transporters in the duodenum. Results:There was a delay of four days following haemolysis before a significant increase in iron absorption was observed. Hepatic hepcidin expression did not decrease until day 3, reaching almost undetectable levels by days 4 and 5. This coincided with the increase in duodenal expression of divalent metal transporter 1, duodenal cytochrome b, and Ireg1. Conclusion: These results suggest that the delayed increase in iron absorption following stimulated erythropoiesis is attributable to a lag in the hepcidin response rather than crypt programming, and are consistent with a direct effect of the hepcidin pathway on mature villus enterocytes.
ACCESSION #
14674401

 

Related Articles

  • erythrocytopoiesis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p806 

    An encyclopedia entry for "erythrocytopoiesis," which refers to erythropoiesis, is presented.

  • erythropoiesis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p807 

    A definition of the term "erythropoiesis," which refers to the formation of red blood cells, is presented.

  • Protection against malaria by anti-erythropoietin antibody due to suppression of erythropoiesis in the liver and at other sites. Tsubata, Shyunsuke; Ebe, Kazuto; Kawamura, Toshihiko; Ishimoto, Yuiko; Tomiyama-Miyaji, Chikako; Watanabe, Hisami; Sekikawa, Hiroho; Aoyagi, Yutaka; Abo, Toru // Immunology & Cell Biology;Dec2005, Vol. 83 Issue 6, p638 

    We have previously reported that erythropoiesis commences in the liver and spleen after malarial infection, and that newly generated erythrocytes in the liver are essential for infection of malarial parasites as well as continuation of infection. At this time, erythropoietin (EPO) is elevated in...

  • Characterization of GATA-1+ hemangioblastic cells in the mouse embryo. Yokomizo, Tomomasa; Takahashi, Satoru; Mochizuki, Naomi; Kuroha, Takashi; Ema, Masatsugu; Wakamatsu, Asami; Shimizu, Ritsuko; Ohneda, Osamu; Osato, Motomi; Okada, Hitoshi; Komori, Toshihisa; Ogawa, Minetaro; Nishikawa, Shin-Ichi; Ito, Yoshiaki; Yamamoto, Masayuki // EMBO Journal;1/10/2007, Vol. 26 Issue 1, p184 

    Hemangioblasts are thought to be one of the sources of hematopoietic progenitors, yet little is known about their localization and fate in the mouse embryo. We show here that a subset of cells co-expressing the hematopoietic marker GATA-1 and the endothelial marker VE-cadherin localize on the...

  • Analysis of unstable behavior in a mathematical model for erythropoiesis. Serna, Susana; Nirody, Jasmine; Rácz, Miklós // Journal of Mathematical Biology;Feb2013, Vol. 66 Issue 3, p595 

    We consider an age-structured model that describes the regulation of erythropoiesis through the negative feedback loop between erythropoietin and hemoglobin. This model is reduced to a system of two ordinary differential equations with two constant delays for which we show existence of a unique...

  • Erythropoietin Has Kidney Protective Efficacy beyond Stimulating Erythropoiesis. Rafieian-Kopaei, Mahmoud; Ghaed-Amini, Fatemeh; Nasri, Hamid // Journal of Isfahan Medical School;Jul2013, Vol. 31 Issue 235, p619 

    Dear Editor-in-Chief, Recently attentions have been made towards the renoprotective property of erythropoietin beyond stimulating erythropoiesis. It has been suggested that carbamylated erythropoietin administration is able to reduce cyclosporine-induced tubulointerstitial damage. Erythropoietin...

  • Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Long, Qiaoming; Huang, Haigen; Shafizadeh, Ebrahim; Liu, Ningai; Lin, Shuo // Nature Cell Biology;Aug2000, Vol. 2 Issue 8, p549 

    Examines the stimulation of erythropoiesis by inhibiting an emerging hematopoietic death receptor in transgenic zebrafish. Sequence and hematopoeitic expression of ZH-DR; Sequence alignment of the cysteine-rich ligand-binding domains of ZH-DR with those of other tumor necrosis factor-related...

  • Involvement of Stromal Membrane-Associated Protein (SMAP-1) in Erythropoietic Microenvironment1. Sato, Yo; Hong, Hea Nam; Yanai, Nobuaki; Obinata, Masuo // Journal of Biochemistry;1998, Vol. 124 Issue 1, p209 

    Erythropoiesis is regulated by the hematopoietic microenvironment of the spleen and fetal liver in mice. We showed that established stromal cells of these organs selectively support erythropoiesis in vitro. To identify the cell surface molecule(s) on the stromal cells involved in erythropoiesis,...

  • Congenital erythropoietic porphyria -- Oral manifestations and dental treatment in childhood: A case report. Fayle, Stephen A.; Pollard, Maxine A. // Quintessence International;Aug1994, Vol. 25 Issue 8, p551 

    Congenital erythropoietic porphyria is a rare condition resulting from an inborn error in prophyrin metabolism. This deficiency leads to hemolytic anemia, photosensitivity, blistering of the skin, and deposition of real-brown pigments in the bones and teeth. The literature regarding the dental...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics