TITLE

Association between a functional in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women

AUTHOR(S)
Yeo, A.; Boyd, P.; Lumsden, S.; Saunders, T.; Handley, A.; Stubbins, M.; Knaggs, A.; Asquith, S.; Taylor, I.; Bahari, B.; Crocker, N.; Rallan, R.; Varsani, S.; Montgomery, D.; Alpers, D. H.; Dukes, G. E.; Purvis, I.; Hicks, G. A.
PUB. DATE
October 2004
SOURCE
Gut;Oct2004, Vol. 53 Issue 10, p1452
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Serotonin (5-hydroxtryptamine, 5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis and secretion, and in sensory signalling in the brain-gut axis. Removal from its sites of action is mediated by a specific protein called the serotonin reuptake transporter (SERT or 5-HTT). Polymorphisms in the promoter region of the SERT gene have effects on transcriptional activity, resulting in altered 5-HT reuptake efficiency. It has been speculated that such functional polymorphisms may underlie disturbance in gut function in individuals suffering with disorders such as irritable bowel syndrome (IBS). The aim of this study was to assess the potential association between SERT polymorphisms and the diarrhoea predominant IBS (dIBS) phenotype. Subjects: A total of 194 North American Caucasian female dIBS patients and 448 female Caucasian controls were subjected to genotyping. Methods: Leucocyte DNA of all subjects was analysed by polymerase chain reaction based technologies for nine SERT polymorphisms, including the insertion/deletion polymorphism in the promoter (SERT-P) and the variable tandem repeat in intron 2. Statistical analysis was performed to assess association of any SERT polymorphism allele with the dIBS phenotype. Results:A strong genotypic association was observed between the SERT-P deletion/deletion genotype and the dIBS phenotype (p = 3.07 ×10-5; n = 194). None of the other polymorphisms analysed was significantly associated with the presence of disease. Conclusions:Significant association was observed between dIBS and the SERT-P deletion/deletion genotype, suggesting that the serotonin transporter is a potential candidate gene for dIBS in women.
ACCESSION #
14674389

 

Related Articles

  • Is there a SERT-ain association with IBS? Camilleri, M. // Gut;Oct2004, Vol. 53 Issue 10, p1396 

    This article reports on the association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome (D-IBS) in women. In a study of 194 North American female participants with D-IBS in a clinical trial programme and 448 female controls,...

  • Association of serotonin transporter genotype with selective processing of smoking-related stimuli in current smokers and ex-smokers. Munaf�, MarcusR.; Johnstone, Elaine C.; Mackintosh, Bundy // Nicotine & Tobacco Research;Oct2005, Vol. 7 Issue 5, p773 

    We sought to determine whether polymorphism in the serotonin transporter (5HTT) gene is associated with attentional bias toward smoking-related stimuli in current smokers and ex-smokers, using a modified Stroop task and an attentional blink task to measure selective processing of smoking-related...

  • 5-HTTLPR and Gender Moderate Changes in Negative Affect Responses to Tryptophan Infusion. Brummett, Beverly H.; Muller, Christopher L.; Collins, Ann L.; Boyle, Stephen H.; Kuhn, Cynthia M.; Siegler, Ilene C.; Williams, Redford B.; Ashley-Koch, Allison // Behavior Genetics;Sep2008, Vol. 38 Issue 5, p476 

    Expression of the serotonin transporter is affected by the genotype of the 5-HTTLPR (short and long forms) as well as the genotype of the SNP rs25531 within this region. Based on the combined genotypes for these polymorphisms, we designated each allele as a high or low expressing allele...

  • Serotonin Transporter Genotype (5-HTTLPR) Predicts Utilitarian Moral Judgments. Marsh, Abigail A.; Crowe, Samantha L.; Yu, Henry H.; Gorodetsky, Elena K.; Goldman, David; Blair, R. J. R. // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Background: The psychological and neurobiological processes underlying moral judgment have been the focus of extensive recent research. Here we show that serotonin transporter (5-HTTLPR) genotype predicts responses to moral dilemmas featuring foreseen harm to an innocent. Methodology/Principal...

  • Serotonin-Related Gene Polymorphisms and Central Nervous System Serotonin Function. Williams, Redford B.; Marchuk, Douglas A.; Gadde, Kishore M.; Barefoot, John C.; Grichnik, Katherine; Helms, Michael J.; Kuhn, Cynthia M.; Lewis, James G.; Schanberg, Saul M.; Stafford-Smith, Mark; Suarez, Edward C.; Clary, Greg L.; Svenson, Ingrid K.; Siegler, Ilene C. // Neuropsychopharmacology;Mar2003, Vol. 28 Issue 3, p533 

    Central nervous system (CNS) serotonergic function affects a wide range of biological and behavioral functions affecting health and disease. Our objective in this study was to determine whether functional polymorphisms of the genes that encode for the serotonin transporter promoter (5HTTLPR) and...

  • Serotonin Transporter Gene Polymorphism and Personality Traits Measured by MMPI. Golimbet, V. E.; Alfimova, M. V.; Sherbatikh, T. V.; Rogaev, E. I. // Russian Journal of Genetics;Apr2003, Vol. 39 Issue 4, p435 

    Polymorphisms of the serotonin transporter gene are known to be associated with some personality traits measured by means of various psychological inventories. In the present work we attempted to find an association between genetic variants of serotonin transporter (loci VNTR-17 and 5-HTTLPR)...

  • Impulsivity and the 5-HTTLPR Polymorphism in a Non- Clinical Sample. Lage, Guilherme M.; Malloy-Diniz, Leandro F.; Matos, Lorena O.; Bastos, Marisa A. R.; Abrantes, Suzana S. C.; Corrêa, Humberto // PLoS ONE;2011, Vol. 6 Issue 2, p1 

    Background: Impulsivity has been associated with serotonergic system functions. However, few researchers have investigated the relationship between a polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) and the different components of impulsivity in a non-clinical...

  • Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting. Grasmäder, Katja; Verwohlt, Petra Louise; Rietschel, Marcella; Dragicevic, Aleksandra; Müller, Matthias; Hiemke, Christoph; Freymann, Nikolaus; Zobel, Astrid; Maier, Wolfgang; Rao, Marie Luise // European Journal of Clinical Pharmacology;Jul2004, Vol. 60 Issue 5, p329 

    Objective. This evaluation focuses on polymorphisms of the cytochrome-P450 (CYP) isoenzymes 2C9, 2C19 and 2D6 and their association with plasma concentrations within a typical clinical setting. Side effects and treatment response were analysed in an exploratory approach in poor and ultra-rapid...

  • IDENTIFICATION OF CARD-15 GENE POLYMORPHISM IN SAHIWAL CATTLE. Soumya, N. P.; Gupta, I. D.; Verma, Archana; Raja, K. N.; Chauhan, Inderasen; Chaudhari, M. V. // Indian Journal of Animal Research;Mar2013, Vol. 47 Issue 1, p83 

    Caspase Activating Recruitment Domain-15 (CARD-15) gene plays an important role in initiation of inflammatory reactions and subsequent immune response. They have been identified as susceptibility loci for inflammatory bowel disease in humans and are, therefore, suitable candidate gene for...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics