The role of Cdx genes in the mammalian gut

Beck, F.
October 2004
Gut;Oct2004, Vol. 53 Issue 10, p1394
Academic Journal
This article presents information on the role of Cdx genes in the mammalian gut. A common feature of genes that impart individual identity to specific segments is the possession of a "homeobox" DNA binding motif coding for a consensus sequence of 60-63 amino acids that acts as a transcriptional regulator of "downstream" genes. It is important to note that in addition to their role in the gut, Cdx genes are active at multiple other sites during early development where, they regulate the extent of ecto/mesodermal expression of Cdx genes and thus also indirectly influence non-intestinal anteroposterior patterning. They are expressed principally in developing ectodermal and mesodermal tissues and in general terms are responsible for segmental specification of the dermatomes, musculoskeletal and nervous systems.


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