TITLE

Association of Cardiovascular Risk Factors to Aortic Valve Calcification as Quantified by Electron Beam Computed Tomography

AUTHOR(S)
Pohle, Karsten; Otte, Merle; Maffert, Ralph; Ropers, Dieter; Schmid, Michael; Daniel, Werner G.; Achenbach, Stephan
PUB. DATE
October 2004
SOURCE
Mayo Clinic Proceedings;Oct2004, Vol. 79 Issue 10, p1242
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To analyze the association among aortic valve calcification, cardiovascular risk factors, and coronary artery calcification using electron beam computed tomography (EBCT). PATIENTS AND METHODS: We analyzed cardiac EBCT data obtained for coronary calcium detection in 1000 consecutively enrolled patients (mean ± SD age, 57.1±10 years; 69% men) between January 1,1998, and July 23, 2001. In all patients, atherosclerotic risk factors (hyperlipidemia, hypertension, diabetes, smoking, and family history of coronary artery disease) were documented. With EBCT, the amount of coronary calcification was determined using the Agatston score, and the amount of aortic valve calcification was measured using a volumetric score. RESULTS: Aortic valve calcification was detected in 177 (17.7%) of the total patient group and was found more frequently In patients with coronary calcification (20.5% in patients with coronary calcium vs 3.8% in patients without coronary caicium; P<.001), hyperlipidemia (19.5% vs 6.5%; P<.001), hypertension (21.7% vs 13.9%; P=.01), or diabetes (30.7% vs 16.6%; P=.002). The volume of aortic valve calcification was significantly higher In patients with vs without hyperlipidemia (P<.001), hypertension (P=.002), and diabetes (P=.001). In a multivariable logistic regression analysis, adjusted for age and sex, hyperlipidemia (P=.001) and the presence of coronary calcification (P<.001) were significant predictors of aortic valve calcification. CONCLUSION: A significant association exists among atherosclerotic risk factors, coronary calcification, and the presence and amount of aortic valve caicificatlon.
ACCESSION #
14656454

 

Related Articles

  • Evolution of coronary artery calcification in patients with chronic kidney disease Stages 3 and 4, with and without diabetes. Stavroulopoulos, Aristeidis; Porter, Christine J.; Pointon, Kate; Monaghan, John M.; Roe, Simon D.; Cassidy, Michael J.D. // Nephrology Dialysis Transplantation;Aug2011, Vol. 26 Issue 8, p2582 

    Background. The purpose of this study was to report the evolution of coronary artery calcification (CAC) in subjects with chronic kidney disease Stages 3 and 4 comparing those with and without diabetes. We previously reported prevalence in the same population.Methods. CAC was measured using...

  • Coronary artery calcification and coronary flow velocity in haemodialysis patients. Caliskan, Yasar; Demirturk, Mustafa; Ozkok, Abdullah; Yelken, Berna; Sakaci, Tamer; Oflaz, Huseyin; Unsal, Abdulkadir; Yildiz, Alaattin // Nephrology Dialysis Transplantation;Aug2010, Vol. 25 Issue 8, p2685 

    Background. Decreased coronary flow reserve (CFR) is a marker of endothelial dysfunction, coronary artery calcification and inflammation, well-known cardiovascular risk factors in haemodialysis (HD) patients. In this study, we aimed to investigate the correlation of coronary artery calcification...

  • Aortic calcification predicts cardiovascular events and all-cause mortality in renal transplantation. Stephanie S. DeLoach; Marshall M. Joffe; Xingchen Mai; Simin Goral; Sylvia E. Rosas // Nephrology Dialysis Transplantation;Apr2009, Vol. 24 Issue 4, p1314 

    Background. Cardiovascular disease is a leading cause of death among renal transplant recipients. Aortic calcification is associated with increased mortality in dialysis subjects. The significance of aortic calcification among renal transplant recipients is unknown. Our objective was to...

  • Coronary artery calcium scoring valuable for assessing cardiovascular risk. Meszaros, Liz // Geriatrics;Jun2007, Vol. 62 Issue 6, p30 

    The article focuses on the value of coronary artery calcium (CAC) scoring in assessing cardiovascular risk. It states that the primary fast computed tomography (CT) methods for CAC measurement are electron-beam CT (EBCT) and multidetector CT (MDCT). According to physician Bruce H. Brundage, a...

  • Do the cardiovascular risk profile and the degree of arterial wall calcification influence the performance of MDCT angiography of lower extremity arteries? Meyer, B.; Werncke, T.; Foert, E.; Kruschewski, M.; Hopfenmüller, W.; Ribbe, C.; Wolf, K.-J.; Albrecht, T. // European Radiology;Feb2010, Vol. 20 Issue 2, p497 

    To retrospectively assess the influence of arterial wall calcifications on the accuracy of run-off computed tomographic angiography (CTA) and to analyse whether cardiovascular risk factors are predictors of compromising calcifications. In 200 consecutive patients who underwent run-off CTA,...

  • Arterial hemodynamics are impaired at rest and following acute exercise in overweight young men. Moore, Stephanie M.; Berrones, Adam J.; Clasey, Jody L.; Abel, Mark G.; Fleenor, Bradley S. // Vascular Medicine;Dec2016, Vol. 21 Issue 6, p497 

    Higher body mass index (BMI) is associated with greater cardiovascular disease (CVD) risk, in part due to aortic stiffening assessed by carotid-femoral pulse wave velocity (cfPWV). Importantly, greater cardiorespiratory fitness (CRF; VO2peak) decreases CVD risk, and is associated with reductions...

  • Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Hruska, Keith; Choi, Eric; Memon, Imran; Davis, T.; Mathew, Suresh // Pediatric Nephrology;Apr2010, Vol. 25 Issue 4, p769 

    Recent advances in our understanding of the excess mortality of chronic kidney disease (CKD) due to cardiovascular complications, obtained through observational studies, demonstrate that vascular calcification and hyperphosphatemia are major cardiovascular risk factors. Mechanistic studies...

  • Relationship between the severity of aortic stenosis and different morphological parameters. Stoicescu, Laurentiu; Duncea, Caius; Buzdugan, Elena; Donca, Valer; Radulescu, Dan // Human & Veterinary Medicine;2014, Vol. 6 Issue 2, p49 

    Introduction and purpose : Research on blood flow in the ascending aorta has demonstrated the association between turbulent blood flow and aortic stenosis, but has not explained the cause. This research aimed to correlate certain morphological features of the aortic orifice generating turbulent...

  • Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study. Kälsch, Hagen; Lehmann, Nils; Mahabadi, Amir A.; Bauer, Marcus; Kara, Kaffer; Hüppe, Patricia; Moebus, Susanne; Möhlenkamp, Stefan; Dragano, Nico; Schmermund, Axel; Stang, Andreas; Jöckel, Karl-Heinz; Erbel, Raimund // Heart;Jun2014, Vol. 100 Issue 12, p930 

    Background Aortic valve calcification (AVC) is considered a manifestation of atherosclerosis. In this study, we investigated whether AVC adds to cardiovascular risk prediction beyond Framingham risk factors and coronary artery calcification (CAC). Methods A total of 3944 subjects from the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics