Antitussive activity of iodo-resiniferatoxin in guinea pigs

Trevisani, M.; Milan, A.; Gatti, R.; Zanosi, A.; Harrison, S.; Fontana, G.; Morice, A. H.; Geppetti, P.
September 2004
Thorax;Sep2004, Vol. 59 Issue 9, p769
Academic Journal
The article focuses on the importance of transient receptor potential vanilloid-1 (TRPV1) antagonists in the treatment of human cough through the antitussive activity of iodo-resiniferatoxin (I-RTX) in guinea pigs. Capsaicin, a well known stimulant of TRPV1, is frequently used in provocation tests to induce cough in experimental animal models and also in man. It states that TRPV1 antagonists can be predicted to be of therapeutic value not only in treatment of cough in patients with asthma and chronic obstructive pulmonary disease (COPD), but also in patients with other inflammatory disease including post viral cough and cough related to gastro-oesophageal reflux.


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