Quantification of tumour response to radiotherapy

Gong Q Y; Eldridge P R; Brodbelt A R; Garc''a-Fi''ana M; Zaman A; Jones B; Roberts N
May 2004
British Journal of Radiology;May2004, Vol. 77 Issue 917, p405
Academic Journal
In 1979, the World Health Organization (WHO) established criteria based on tumour volume change for classifying response to therapy as (i) progressive disease (PD), (ii) partial recovery (PR), and (iii) no change (NC). Typically, the tumour volume is reported from diameter measurements, using the calliper method. Alternatively, the Cavalieri method provides unbiased volume estimates of any structure without assumptions about its shape. In this study, we applied the Cavalieri method in combination with point counting to investigate the changes in tumour volume in four patients with high grade glioma, using 3D MRI. In particular, the volume of tumour within the enhancement boundary, the enhancing abnormality (EA), was estimated from T(1) weighted images, and the volume of the non-enhancing abnormality, (NEA) enhancing abnormality, was estimated from T(2) relaxation time and magnetic transfer ratio tissue characterization maps. We compared changes in tumour volume estimated by the Cavalieri method with those obtained using the calliper method. Absolute tumour volume differed significantly between the two methods. Analysis of relative change in tumour volume, based on the WHO criteria, provided a different classification using the calliper and Cavalieri methods. The benefit of the Cavalieri method over the calliper method in the estimation of tumour volume is justified by the following factors. First, Cavalieri volume estimates are mathematically unbiased. Second, the Cavalieri method is highly efficient under an appropriate sampling density (i.e. EA volume estimates can be obtained with a coefficient of error no higher than 5% in 2-3 min). Third, the source of variation of the volume estimates due to disagreements between observers, and within observer, is much greater in the positioning of the calliper diameters than in the identification of the tumour boundaries when applying the Cavalieri method. Additionally, the error prediction formula, available to estimate the coefficient of error of Cavalieri volume estimates from the data, allows us to establish more precise classification criteria against which to identify potentially clinical significant changes in tumour volume.


Related Articles

  • How Skilled are you? Pratt, Shaaron; Rogers, Hywel; Gambling, Tina; Brown, Paul // Synergy: Imaging & Therapy Practice;Aug2009, p18 

    The article focuses on an audit conducted by the Society and College of Radiographers (SCoR) which is designed to identify the knowledge and skills of radiographers in line with their dependency on information management and technology (IM&T) to support their practice in Great Britain. It notes...

  • Modular MRI Proves an Attractive Option. Vasko, Cat // Imaging Economics;Oct2008, Vol. 21 Issue 10, p14 

    The article focuses on the usefulness of the modular magnetic resonance imaging (MRI) at the Concord Hospital in New Hampshire. Dr. Jay Mazurowski, director of radiology services at the hospital, suggested the modular MRI when the hospital needed an MRI suite for its new 3T system. Mazurowski...

  • Arc therapy: A revolution in radiotherapy. Helyer, Sarah; Stephenson, Nicky; Heaton, Angela // Synergy: Imaging & Therapy Practice;Aug2009, p12 

    The article focuses on the usage of several radiotherapy equipment in hospitals that include Radiotherapy CT scanning along with the potential of positron emission tomography (PET) and magnetic resonance imaging (MRI) leading to a more precise localization of the target or tumour volume. It...

  • A financial checkup--for radiology services. Hensley, Scott // Modern Healthcare;11/30/98, Vol. 28 Issue 48, p44 

    Discusses the charges for radiology services. Cost of each radiology procedure; Comment from Laura Shapiro, a manager in the business consulting arm of Siemens Medical Systems in New Jersey; Requirement of figuring the cost of every unit of radiology service.

  • Salvage Cryosurgery for Recurrent Prostate Carcinoma after Radiotherapy. Andrea B. Galosi; Franco Lugnani; Giovanni Muzzonigro // Journal of Endourology;Jan2007, Vol. 21 Issue 1, p1 

    Cryotherapy is a salvage treatment for patients with biopsy-proved prostatic adenocarcinoma recurrent after radiotherapy. Proper sampling, labeling, and analysis of prostate biopsies allows prompt diagnosis, identification of important prognostic parameters, and planning of an appropriate...

  • New fluoroscopy unit for Tauranga.  // New Zealand Doctor;5/5/2010, p6 

    The article reports that the radiology department of Tauranga Hospital in New Zealand has acquired a digital fluoroscopy screening unit.

  • Current Treatment of DCIS. Choy, Christina; Mokbel, Kefah // Journal of Cancer Therapy;Feb2014, Vol. 5 Issue 5, p179 

    Ductal carcinoma in-situ DCIS is a heterogeneous entity in breast neoplasm with unpredictable biological behavior. This poses challenge in the management of DCIS. Various trials on DCIS have shown good outcome with integral treatment of adequate surgery, radiotherapy and hormonal therapy....

  • What can Nuclear Medicine Physicians and Radiologists do for Global Health? Aung Zaw Win // World Journal of Nuclear Medicine;Jan-Apr2016, Vol. 15 Issue 1, p1 

    The author reflects on the emerging field of global radiology that integrates radiology and global health and seeks to increase access to radiological services.

  • Waiting times for treatment of rectal cancer in North West England. Duff, S. E.; Wood, C.; McCredie, V.; Levine, E.; Saunders, M. P.; O'Dwyer, S. T. // Journal of the Royal Society of Medicine;Mar2004, Vol. 97 Issue 3, p117 

    An interim goal of the NHS National Cancer Plan is that, by 2005, patients with cancer should be treated within one month of diagnosis and within two months from urgent general practitioner referral. Preoperative radiotherapy for rectal cancer reduces the risk of local recurrence and may...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics