Review: Thoracoscopic pleurodesis with talc may be the optimal technique in patients with malignant pleural effusion

Mathur, Praveen N.
September 2004
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p43
Academic Journal
This article focuses on treatment of patients with malignant pleural effusion. Randomized Controlled Trials (RCTs) in any language of patients > 16 years of age having pleurodesis for pleural effusion in the context of metastatic cancer or a malignant process leading to pleural effusion that compared any sclerosant with other sclerosants, or rhoracoscopic pleurodesis with bedside pleurodesis were selected. 36 RCTs (1499 patients) with sample sizes ranging from 19 to 95 patients met the inclusion criteria. In 10 RCTs (308 patients), talc was more effective than other sclerosants (bleomycin, tetracycline, mustine, and drainage alone) for pleurodesis. In 4 RCTs (143 patients), Corynebacterium parvum was more effective than other sclerosants (bleomycin and tetracycline) for pleurodesis.


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