Etanercept plus methotrexate reduced symptoms and disease activity in adult-onset rheumatoid arthritis

Shoor, Stanford
September 2004
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p42
Academic Journal
This article discusses therapeutic effect of the combination of Etanercept (ENC) and Methotrexate (MTX) compared with each treatment alone in patients with Rheumatoid Arthritis (RA). 682 patients > 18 years of age (mean age 53 y, 77% women) who had diagnosed, active adult-onset RA (defined as≥ 10 swollen and≥ 12 painful joints, and≥ 1 of the following: erythrocyte sedimentation rate≥ 28 mm/h, plasma C-reactive protein≥ 20 mg/L, or morning stiffness for≥ 45 min) for 6 months to 20 years (mean disease duration 6.6 y) were investigated. Patients were allocated to ENC (25 mg subcutaneously twice weekly) (n 223), MTX (7.5 mg increased to 20-mg oral capsules once per wk within 8 wk if patients had any painful or swollen joints) (n-228), or ENC plus MTX (combination group, n = 231).


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