Postexposure prophylaxis with oseltamivir reduced influenza transmission in households

Gross, Peter A.
September 2004
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p40
Academic Journal
This article investigates whether Household Contacts (HHCs) (after treatment of all index influenza patients with oseltamivir), is postexposure prophylaxis (PEP) more effective than treatment with oseltamivir at the time of developing illness (expectant treatment) for preventing influenza (flu) transmission in households. 812 HHCs (age range 1 to 83 y, 55% girls/women) of index patients presenting with a flu-like illness during a documented community flu outbreak were studied. All index patients and HHCs developing illness in the expectant treatment group received oseltamivir treatment (adults and adolescents 75-mg capsules and children 1 to 2, 3 to 5, and 5 to 12 y of age, 30-, 45-, and 60-mg suspension, respectively, twice daily) for 5 days, beginning within 48 hours of the reported onset of symptoms.


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