TITLE

Memantine was better than placebo in Alzheimer disease already being treated with donepezil

AUTHOR(S)
Hirsch, Calvin H.
PUB. DATE
September 2004
SOURCE
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p38
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article investigates that treatment of patients with moderate to severe Alzheimer Disease (AD) with memantine was better than placebo. 404 patients ≥ 50 years of age (mean age 76 y, 65% women) with a diagnosis of probable AD, a mini-mental state examination score of 5 to 14, ongoing donepezil therapy for ≥ 6 months at a stable dose (5 to 10 mg/d) for≥ 3 months, a knowledgeable and reliable caregiver, ambulatory ability, and a stable medical condition were studied. Patients who received memantine had greater improvement than patients who received placebo in all cognitive, functional, and global outcome measures at 24 weeks.
ACCESSION #
14590723

 

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