Doubling the dose of inhaled corticosteroids during asthma deterioration did not improve asthma control

Schünemann, Holger J.
September 2004
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p37
Academic Journal
This article investigates whether double dose of inhaled corticosteroid prevents asthma exacerbations. 390 patients who were ≥ 16 years of age (mean age 49 y, 67% women) with a clinical diagnosis of asthma were taken as the reference group. Patients recorded their peak flow and symptom scores for 28 days during which time they were started on 10 days of prednisolone, 30 mg/d, if asthma control deteriorated to a point at which they would normally start oral corticosteroids, or peak flow decreased by 40%. Doubling the dose of inhaled corticosteroids when asthma control begins to deteriorate did not reduce the need to start prednisolone and did not affect change in mean peak flow or asthma symptom scores.


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