An antibiotic regimen for 8 days was as effective as one for 15 days in ventilator-associated pneumonia

Marshall, John C.
September 2004
ACP Journal Club;Sep/Oct2004, Vol. 141 Issue 2, p30
Academic Journal
This article focuses on an alternate therapy for treatment of Ventilator-Associated Pneumonia (VAP). In patients with microbiologically proven VAP, an 8-day course of antibiotics as effective as (noninferior to) a 15-day course with respect to all-cause mortality, pulmonary infection recurrence, and antibiotic-free days. 402 patients more than 18 years of age who received mechanical ventilation for ≥ 48 hours and developed objectively documented (by quantitative culture results of bronchoscopic specimens) VAP. Patients were stratified by center and allocated to an antibiotic regimen (selected by the treating physician) for 8 days (n = 197) or 15 days (n = 204).


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