Development of a biosensor based on laser-fabricated polymer microcantilevers

Zhang, X. Richard; Xianfan Xua
September 2004
Applied Physics Letters;9/20/2004, Vol. 85 Issue 12, p2423
Academic Journal
We develop high-sensitivity biosensors based on microcantilevers. The polymer microcantilevers are fabricated by fast and cost-effective laser machining processes. Polymer film is selected because it gives better sensitivity of deflection measurements than silicon due to its lower Young's modulus and also its cost is much lower. We demonstrate using these polymer microcantilevers for biological molecular analysis in a DNA hybridization experiment. It is shown that our biosensor is capable of detecting 12 base oligonucleotide with concentrations as low as 0.01 μM.


Related Articles

  • Biospecific Interaction Analysis (BIA) as a Tool for the Design and Development of Gene Transcription Modifiers. Gambari, R. // Current Medicinal Chemistry - Anti-Cancer Agents;Nov2001, Vol. 1 Issue 3, p277 

    The applications of surface plasmon resonance (SPR) and biosensor technology for biospecific interaction analysis (BIA) of molecular interactions between transcription modifiers and target biomolecules is here described for the identification of possible candidates for drug research and...

  • Towards a fast-responding, label-free electrochemical DNA biosensor. Mir, M.; Katakis, I. // Analytical & Bioanalytical Chemistry;Mar2005, Vol. 381 Issue 5, p1033 

    DNA sensors and sensor arrays (biochips) have become an important tool in molecular biology and biotechnology in recent years. For low-throughput, easy-to-use devices it is desirable that they be of low cost, reagentless, and label-free. Displacement sensors with electrochemical detection offer...

  • Label free biosensor incorporating a replica-molded, vertically emitting distributed feedback laser. Lu, M.; Choi, S. S.; Wagner, C. J.; Eden, J. G.; Cunningham, B. T. // Applied Physics Letters;6/30/2008, Vol. 92 Issue 26, p261502 

    A label free biosensor based upon a vertically emitting distributed feedback (DFB) laser has been demonstrated. The DFB laser comprises a replica-molded, one-dimensional dielectric grating coated with laser dye-doped polymer as the gain medium. Adsorption of biomolecules onto the laser surface...

  • Applications of Aptasensors in Clinical Diagnostics. Ping Hong; Wenli Li; Jinming Li // Sensors (14248220);2012, Vol. 12 Issue 2, p1181 

    Aptamers are artificial oligonucleotides (DNA or RNA) selected in vitro that bind a broad range of targets with high affinity and specificity; a sensitive yet simple method to utilize aptamers as recognition elements for the development of biosensors (aptasensors) is to transduce the signal...

  • Biomimetic piezoelectric quartz sensor for caffeine based on a molecularly imprinted polymer. Ebarvia, Benilda S.; Binag, Christina A.; Sevilla III, Fortunato // Analytical & Bioanalytical Chemistry;Mar2004, Vol. 378 Issue 5, p1331 

    A piezoelectric quartz sensor coated with molecularly imprinted polymer (MIP) for caffeine was developed. The MIP was prepared by co-polymerizing methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) in the presence of azobis(isobutyronitrile) as initiator, caffeine as template...

  • Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery. Lei Ye; Haupt, Karsten // Analytical & Bioanalytical Chemistry;Apr2004, Vol. 378 Issue 8, p1887 

    Biological receptors play an important role in affinity-based drug assays, biosensors, and at different stages during the modern drug discovery process. The molecular imprinting technology that has recently emerged has shown great potential for producing biomimetic receptors that challenge their...

  • Poly (N-isopropylacrylamide) Microgel-Based Optical Devices for Sensing and Biosensing. Islam, Molla R.; Ahiabu, Andrews; Xue Li; Serpe, Michael J. // Sensors (14248220);May2014, Vol. 14 Issue 5, p8984 

    Responsive polymer-based materials have found numerous applications due to their ease of synthesis and the variety of stimuli that they can be made responsive to. In this review, we highlight the group's efforts utilizing thermoresponsive poly (N-isopropylacrylamide) (pNIPAm) microgel-based...

  • Immobilization of HRP in Mesoporous Silica and Its Application for the Construction of Polyaniline Modified Hydrogen Peroxide Biosensor. Chien-Chung Chen; Jing-Shan Do; Yesong Gu // Sensors (14248220);2009, Vol. 9 Issue 6, p4635 

    Polyaniline (PANI), an attractive conductive polymer, has been successfully applied in fabricating various types of enzyme-based biosensors. In this study, we have employed mesoporous silica SBA-15 to stably entrap horseradish peroxidase (HRP), and then deposited the loaded SBA-15 on the PANI...

  • Tracking drug levels in blood in real time.  // Nature Reviews Drug Discovery;Jan2014, Vol. 13 Issue 1, p9 

    The article offers information on the oligonucleotide-based biosensor which offers continuous and real-time monitoring of drug dosages in patients.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics