They're bugs, Jim, but not as we know them

September 2004
Gut;Sep2004, Vol. 53 Issue 9, p1385
Academic Journal
The article discusses about various bacterial antigens that have been revealed in chronic inflammation in colitis and crohn's disease through pathogenesis. There is a relatively small number of immunodominant antigens that stimulate pathological T cell responses. Specific bacterial antigens driving experimental inflammatory bowel disease by a technique called serological position cloning have been identified, which screens DNA libraries with defined antisera. Strong reactivity against flagellins was witnessed in many models of colitis.


Related Articles

  • Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies. Fantini, Massimo C.; Pallone, Francesco; Monteleone, Giovanni; Cario, Elke; Mizoguchi, Emiko // World Journal of Gastroenterology;5/28/2009, Vol. 15 Issue 20, p2472 

    Spondyloarthropathies (SpA) are commonly observed extra-intestinal manifestations of both Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD). However, the immunological link between these two clinical entities is still poorly understood....

  • Mucosal T Cell Proliferation and Apoptosis in Inflammatory Bowel Disease. Sturm, Andreas; De Souza, Heitor S. P.; Fiocchi, Claudio // Current Drug Targets;May2008, Vol. 9 Issue 5, p381 

    Both forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), represent prototypical conditions whose most salient features are the presence of chronic inflammation involving various parts of the intestinal tract and an increased risk of cancer, which is a...

  • Dextran Sulfate Sodium Inhibits Alanine Synthesis in Caco-2 Cells. Zhong Ye; Mishchuk, Darya O.; Stephens, Natasha S.; Slupsky, Carolyn M. // International Journal of Molecular Sciences;Apr2011, Vol. 12 Issue 4, p2325 

    To understand and characterize the pathogenic mechanisms of inflammatory bowel disease, dextran sulfate sodium (DSS) has been used to induce acute and chronic colitis in animal models by causing intestinal epithelium damage. The mechanism of action of DSS in producing this outcome is not well...

  • Autophagy gets the ‘NOD’ to enhance bacterial handling and antigen presentation. Shin, Jin Na; Eissa, N. Tony // Immunology & Cell Biology;May/Jun2010, Vol. 88 Issue 4, p343 

    In this article the authors discuss the study about autophagy that gets the nucleotide-binding oligermization domaincontaining (NOD) to enhance bacterial handling and antigen presentation. They cites the study of R. Cooney which shows that NOD2 induces autophagy in human dendritic cells that...

  • Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn's Disease Patients and Possible Involvement of EGR1. Yu, Wei; Lin, Zhenwu; Hegarty, John; Chen, Xi; Kelly, Ashley; Wang, Yunhua; Poritz, Lisa; Koltun, Walter // Inflammation;Jun2012, Vol. 35 Issue 3, p889 

    Ulcerative colitis (UC) and Crohn's disease (CD) are two related yet different forms of chronic intestinal inflammation. We investigated the genes regulated by NKX2-3 in B cells from a UC patient by cDNA microarray and compared the results to those genes regulated by NKX2-3 in B cells from a CD...

  • Identification of Disease-Associated DNA Methylation in B Cells from Crohn's Disease and Ulcerative Colitis Patients. Lin, Zhenwu; Hegarty, John; Yu, Wei; Cappel, Jon; Chen, Xi; Faber, Pieter; Wang, Yunhua; Poritz, Lisa; Fan, Jian-Bing; Koltun, Walter // Digestive Diseases & Sciences;Dec2012, Vol. 57 Issue 12, p3145 

    Background: Changes in the methylation status of inflammatory bowel disease (IBD)-associated genes could significantly alter levels of gene expression, thereby contributing to disease onset and progression. We previously identified seven disease-associated DNA methylation loci from intestinal...

  • Fenotipo e historia natural de la enfermedad inflamatoria intestinal en un centro de referencia en Medell�n-Colombia. Ba�os, Fabi�n Juliao; V�lez, Mario Hern�n Ruiz; Arango, Jos� Fernando Fl�rez; G�mez, Jorge Hernando Donado; Zuluaga, Juan Ignacio Mar�n; Arango, Claudia Monsalve; G�mez, Carlos Andr�s Jim�nez; Zapata, Yineth Agudelo; Velayos, Fernando S. // Revista Colombiana de Gastroenterolog�a;Jul2012, Vol. 25 Issue 3, p240 

    Worldwide the frequencies of inflammatory bowel disease, ulcerative colitis and Crohn�s disease have all increased. In our own environment it has become necessary to establish the epidemiology of these entities and to determine their clinical and endoscopic behavior. Methodology: This is a...

  • In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis. Bridger, S.; Lee, J.C.W.; Bjarnason, I.; Lennard Jones, J.E.; Macpherson, A.J. // Gut;Jul2002, Vol. 51 Issue 1, p21 

    Background and aims: Smoking tobacco has opposite effects on the different forms of inflammatory bowel disease (IBD). It predisposes to the development of Crohn's disease (CD) yet is associated with a reduced incidence of ulcerative colitis (UC). We have studied sib pairs discordant for both...

  • Inflammatory bowel disease. O'Malley, John; Spinks, Julian // Pulse;5/25/2011, Vol. 71 Issue 19, p16 

    The article presents questions and answers related to irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), including the diagnostic process of IBD, what drug therapy to treat Crohn's disease, and the risk of cancer with ulcerative colitis.


Read the Article


Sign out of this library

Other Topics