TITLE

They're bugs, Jim, but not as we know them

PUB. DATE
September 2004
SOURCE
Gut;Sep2004, Vol. 53 Issue 9, p1385
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses about various bacterial antigens that have been revealed in chronic inflammation in colitis and crohn's disease through pathogenesis. There is a relatively small number of immunodominant antigens that stimulate pathological T cell responses. Specific bacterial antigens driving experimental inflammatory bowel disease by a technique called serological position cloning have been identified, which screens DNA libraries with defined antisera. Strong reactivity against flagellins was witnessed in many models of colitis.
ACCESSION #
14434530

 

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