TITLE

Testing for faecal calprotectin (PhiCal) in the Norwegian Colorectal Cancer Prevention trial on flexible sigmoidoscopy screening

AUTHOR(S)
Hoff, G.; Grolmol, T.; Thiis-Evensen, E.; Bretthauer, M.; Gondal, G.; Vatn, M. H.
PUB. DATE
September 2004
SOURCE
Gut;Sep2004, Vol. 53 Issue 9, p1329
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Screening for colorectal cancer (CRC) using guaiac based fecal occult blood tests (FOBT) has an estimated programme sensitivity of >60% but <30% for strictly asymptomatic CRC in a single screening round. In search for improved non-invasive tests for screening, we compared a test for faecal calprotectin (PhiCal) with a human haemoglobin immunochemical FOBT (FlexSure OBT). Methods: In the Norwegian Colorectal Cancer Prevention (NORCCAP) trial, screenees in one screening arm were offered screening with combined flexible sigmoidoscopy (FS) and FlexSure OBT. They were also requested to bring a fresh frozen sample of stool for the PhiCal test which was performed on samples from screenees with CRC (n = 16), high risk adenoma (n = 195), low risk adenoma (n = 592), and no adenoma (n = 1518) (2321 screenees in total). A positive PhiCal test was defined by a calprotectin level ⩾50 μg/g. Results: The PhiCal test was positive in 24-27% of screenees whether they had no adenoma, low risk adenoma, or high risk adenoma. Ten (63%) of 16 CRCs gave a positive PhiCal test. The total positivity rate in this population was 25% for the PhiCal test compared with 12% for FlexSure OBT, with a sensitivity for advanced neoplasia of 27% and 35%, respectively. Specificity for "any neoplasia" was 76% for the PhiCal test and 90% for FlexSure OBT. Conclusions: In colorectal screening, the performance of the PhiCal test on a single spot from one stool sample was poorer than a single screening round with FlexSure OBT and cannot be recommended for population screening purposes. The findings indicate a place for FlexSure OBT in FOBT screening.
ACCESSION #
14434519

 

Related Articles

  • Sigmoidoscopy screening for colorectal cancer. Imperiale, Thomas F. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;6/6/2009, Vol. 338 Issue 7707, p1339 

    The author explores the effectiveness of sigmoidoscopy screening in reducing mortality from colorectal cancer. He presents the findings of the Norwegian Colorectal Cancer Prevention (NORCCAP) trial, which support the assumption that such screening reduces mortality. He explains the reason for...

  • Colorectal cancer in Italy: a review of current national and regional practice on screening and treatment. Masseria, Cristina // European Journal of Health Economics;2010 Supplement 1, Vol. 10, p41 

    Colorectal cancer (CRC) is one of the most prevalent and deadly cancers in Italy. Its burden is expected to remain significant in the coming years, although it is mostly a preventable disease. Prevention and screening programmes will play an important role in the fight against CRC. A national...

  • Bowel Ca screening reduces mortality.  // Pulse;12/5/2007, Vol. 67 Issue 44, p10 

    The article discusses the decrease of emergency diagnoses of colorectal cancer through a bowel cancer screening program in Great Britain. It states that the reduction, accompanied by a sharp fall in 30-day mortality, was partly due to a change of attitudes and referral patterns of general...

  • Screening colonoscopy: Is it time? Simon, Jerome B. // CMAJ: Canadian Medical Association Journal;11/14/2000, Vol. 163 Issue 10, p1277 

    Examines the debate surrounding the health benefits of periodic surveillance colonoscopy. Inadequacy of fecal occult blood testing (FOBT) and sigmoidoscopy for middle-aged and elderly patients at risk for colorectal cancer; Details of a study of the use of colonoscopy in general population...

  • Screening Sigmoidoscopy— How Often and How Good? Fletcher, Robert H. // JAMA: Journal of the American Medical Association;7/2/2003, Vol. 290 Issue 1, p106 

    Editorial. Focuses on screening sigmoidoscopy, which is used in the diagnosis of colorectal cancer. Questions as to how often the procedure should be repeated; The imperfect nature of screening tests; How most colorectal cancer deaths can be prevented with early detection.

  • The Effect of Attending a Flexible Sigmoidoscopic Screening Program on the Prevalence of Colorectal Adenomas at 13-Year Follow-Up. Thiis-Evensen, Espen; Hoff, Geir S.; Sauar, Jostein; Majak, Bernhard M.; Vatn, Morten H. // American Journal of Gastroenterology;Jun2001, Vol. 96 Issue 6, p1901 

    OBJECTIVES: Understanding the epidemiology of colorectal adenomas is a prerequisite for designing follow-up programs after polypectomy. The aim of the study was to investigate the effect of polypectomy on the long-term prevalence of adenomas. METHODS: In 1983, a total of 799 men and women aged...

  • TIMELY COLORECTAL CANCER SCREENING IN AFRICAN AMERICANS. Griffith, Kathleen; Plowden, Keith; McGuire, Deborah; Royak-Schaler, Renee; Steinberger, Eileen; Jenkins, Louise // Oncology Nursing Forum;Mar2007, Vol. 34 Issue 2, p558 

    African Americans have low rates of colorectal cancer (CRC) screening, and little is known about factors influencing their participation. This study sought to identify biological, psychosocial/behavioral, and social factors that predicted timely CRC screening (i.e. completion of risk-appropriate...

  • TEST MAY REDUCE DEATH RATE FROM COLORECTAL CANCER.  // Cleveland Clinic Men's Health Advisor;Aug2012, Vol. 14 Issue 8, p2 

    The article reports on the study published in the "New England Journal of Medicine" on May 21, 2012, which revealed that screening of colorectal cancer through flexible sigmoidoscopy may reduce deaths and may prevent new cases.

  • Digestive Disease Week: New England Journal of Medicine.  // Biomedical Market Newsletter;5/25/2012, Vol. 21, p1 

    The article offers information on a study related with efficacy of flexible sigmoidoscopy in reduction of colorectal cancer rates.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics