High incidence of adenocarcinoma arising from the right side of the gastric cardia in NW Iran

Derakhshan, M. H.; Yazdonbod, A.; Sodjadi, A. R.; Shokoohi, B.; McColl, K. E. L.; Malekzadeh, R.
September 2004
Gut;Sep2004, Vol. 53 Issue 9, p1262
Academic Journal
Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, with cancer of the cardia increasing in incidence and that of the more distal stomach decreasing. NW Iran has a very high incidence of upper gastrointestinal cancer and we have examined the anatomical site specific incidence in this geographical region. Method and Materials: Of 33 718 patients who visited our clinic from March 2000 to Jan 2003, 3119 (9.3%) with persistent upper gastrointestinal symptoms underwent upper gastrointestinal fibreoptic endoscopy. Exact tumor site, subsite, and axial view were determined. Demographic data including age, sex, and place of residence were assessed. Using matched data from the cancer registry and endoscopic survey, age standardized rates (AR) for all subsites were calculated. Results: Upper gastrointestinal cancer was diagnosed histologically in 499 patients (16.0%). The most frequent site was the gastric cardia (126 (25.3%)) followed by the oesophageal body (90 (18.0%)), antrum (82 (16.4%)), corpus (74 (14.8%)), distal oesophagus (57 (11.4%)), gastro-oesophageal junction (47 (9.4%)), and proximal oesophagus (22 (4.4%)). From axial views of the cardia, 51.4% and 6.8% of tumors were found to originate from the lesser and greater curve, respectively. ASR for gastric cancer were 51.2 in males and 15.4 in females. Cardia cancer with ASR of 26.4 in males and 8.6 in females was the major component of gastric cancer. Conclusion: NW Iran is a geographical region with a very high incidence of cardia cancer and with the great majority originating from the right side of the cardia. This suggests a locally acting luminal carcinogen. Studying the aetiology of this cancer in NW Iran is likely to increase our understanding of the rising incidence of this cancer throughout the Western world.


Related Articles

  • Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report. Yamamoto, Daigo; Hamada, Yoshinori; Tsubota, Yu; Kawakami, Katsuhiro; Yamamoto, Chizuko; Yamamoto, Mitsuo // World Journal of Surgical Oncology;2012, Vol. 10 Issue 1, p1 

    Background: Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. Case presentation: We report a case of the coexistence of adenocarcinoma and gastrointestinal...

  • Endoscopic ultrasonography for diagnosis of submucosal invasion in early gastric cancer. Matsumoto, Yusuke; Yanai, Hideo; Tokiyama, Hiroshi; Nishiaki, Makoto; Higaki, Shingo; Okita, Kiwamu // Journal of Gastroenterology;2000, Vol. 35 Issue 5, p326 

    Abstract: Endoscopic ultrasonography (EUS) is considered to be useful for deciding the treatment course for early gastric cancer. To determine reliable indications suggesting submucosal tumor invasion, we retrospectively analyzed EUS images of the hyperechoic third layer, which corresponds to...

  • Focal Intramucosal Adenocarcinoma Occurring in Gastric Hyperplastic Polyps: Two Case Reports. Taniuchi, Keisuke; Okada, Mitsuo; Sakaeda, Hiroshi // Case Reports in Gastrointestinal Medicine;8/4/2015, Vol. 2015, p1 

    Gastric hyperplastic polyps are generally considered benign lesions, although rare cases of adenocarcinoma have been reported. Two cases of intramucosal adenocarcinoma originating from gastric hyperplastic polyps that were successfully removed by endoscopic mucosal resection or endoscopic...

  • A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro. Schlaermann, Philipp; Toelle, Benjamin; Berger, Hilmar; Schmidt, Sven C.; Glanemann, Matthias; Ordemann, Jürgen; Bartfeld, Sina; Mollenkopf, Hans J.; Meyer, Thomas F. // Gut;Feb2016, Vol. 65 Issue 2, p202 

    Background and aims Helicobacter pylori is the causative agent of gastric diseases and the main risk factor in the development of gastric adenocarcinoma. In vitro studies with this bacterial pathogen largely rely on the use of transformed cell lines as infection model. However, this approach is...

  • Do All Prostate Cancers Behave the Same? Thusitha, Dissanayake; Elizabeth, Arze; Mailien, Rogers // Journal of Cancer Therapy;Nov2013, Vol. 4 Issue 9, p1426 

    Two different immunohistochemical types suggestive of Large Cell Neuroendocrine (NE) carcinoma and Adenocarcinoma in a patient with known diffusely metastatic, hormone refractory prostate carcinoma are rarities. Interestingly, our patient had documented history of exposure to Agent Orange during...

  • Differential Pathologic Variables and Outcomes across the Spectrum of Adenocarcinoma of the Esophagogastric Junction. Reynolds, John V.; Ravi, Narayanasamy; Muldoon, Cian; Larkin, John O.; Rowley, Suzanne; O'Byrne, Ken; Hollywood, Donal; O'Toole, Dermot // World Journal of Surgery;Dec2010, Vol. 34 Issue 12, p2821 

    Background: Adenocarcinoma of the esophagogastric junction (AEG) as described by Siewert et al. is classified as one entity in the latest (7th Edition) American Joint Cancer Committee/International Union Against Cancer (AJCC/UICC) manual, compared with the previous mix of esophageal and gastric...

  • A Composite Adenoendocrine Carcinoma of the Stomach Arising from a Neuroendocrine Tumor. Ronellenfitsch, Ulrich; Ströbel, Philipp; Schwarzbach, Matthias H. M.; Staiger, Wilko I.; Gragert, Dieter; Kähler, Georg // Journal of Gastrointestinal Surgery;Nov2007, Vol. 11 Issue 11, p1573 

    Gastric neuroendocrine tumors (carcinoids) are relatively uncommon neoplasms. Some 70 to 80% of these lesions occur in patients with autoimmune body gastritis. This disorder, however, is also a risk factor for the development of conventional gastric adenocarcinomas. We report a case of a patient...

  • Expression of cagA, virB/D Complex and/or vacA Genes in Helicobacter pylori Strains Originating from Patients with Gastric Diseases. Szkaradkiewicz, Andrzej; Karpiński, Tomasz M.; Linke, Krzysztof; Majewski, Przemysław; Rożkiewicz, Dorota; Goślińska-Kuźniarek, Olga // PLoS ONE;2/11/2016, Vol. 11 Issue 2, p1 

    In order to better understand pathogenicity of Helicobacter pylori, particularly in the context of its carcinogenic activity, we analysed expression of virulence genes: cagA, virB/D complex (virB4, virB7, virB8, virB9, virB10, virB11, virD4) and vacA in strains of the pathogen originating from...

  • Therapeutic Decision-Making Using Endoscopic Ultrasonography in Endoscopic Treatment of Early Gastric Cancer. Jong Yeul Lee; Il Ju Choi; Chan Gyoo Kim; Soo-Jeong Cho; Myeong-Cherl Kook; Keun Won Ryu; Young-Woo Kim // Gut & Liver;Jan2016, Vol. 10 Issue 1, p42 

    Background/Aims: We evaluated the effectiveness of an endoscopic ultrasonography (EUS)-based treatment plan compared to an endoscopy-based treatment plan in selecting candidates with early gastric cancer (EGC) for endoscopic submucosal dissection based on the prediction of invasion depth....


Read the Article


Sign out of this library

Other Topics