Experimental Helicobacter pylori infection in humans: a multifaceted challenge

Michetti, P.
September 2004
Gut;Sep2004, Vol. 53 Issue 9, p1220
Academic Journal
The article examines the scientific rationale for the use of an infection challenge model for helicobacter pylori vaccine development in humans. Challenge experiments have been an important method of studying the pathogenesis of many infectious diseases and of evaluating initial efficacy of vaccines before large scale field tests are conducted. Very few information is available about the precise mode of infection of helicobacter pylori. This infection is typically acquired in childhood but most studies related to helicobacter pylori pathogenesis and host response are conducted, for obvious ethical and practical reasons in adults.


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