TITLE

Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes

AUTHOR(S)
Hulme, John S.; Barratt, Bryan J.; Twells, Rebecca C.J.; Cooper, Jason D.; Lowe, Chris E.; Howson, Joanna M.M.; Lam, Alex C.; Smink, Luc J.; Savage, David A.; Undlien, Dag E.; Guja, Cristian; Ionescu-Tîrgoviste, Constantin; Tuomilehto-Wolf, Eva; Tuomilehto, Jaakko; Todd, John A.
PUB. DATE
September 2004
SOURCE
Diabetes;Sep2004, Vol. 53 Issue 9, p2479
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Prior data associating the expression of lymphocyte-specific protein tyrosine kinase (LCK) with type 1 diabetes, its critical function in lymphocytes, and the linkage of the region to diabetes in the nonobese diabetic (NOD) mouse model make LCK a premier candidate for a susceptibility gene. Resequencing of LCK in 32 individuals detected seven single nucleotide polymorphisms (SNPs) with allele frequencies >3%, including four common SNPs previously reported. These and six other SNPs from dbSNP were genotyped in a two-stage strategy using 2,430 families and were all shown not to be significantly associated with type 1 diabetes. We conclude that a major role for the common LCK polymorphisms in type 1 diabetes is unlikely. However, we cannot tale out the possibility of there being a causal variant outside the exonic, intronic, and untranslated regions studied. Diabetes 53:2479-2482, 2004
ACCESSION #
14414339

 

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