Phase-resolved optical Doppler tomography for imaging flow dynamics in microfluidic channels

Lei Wang; Wei Xu; Mark Bachman; Li, G. P.; Zhongping Chen
September 2004
Applied Physics Letters;9/6/2004, Vol. 85 Issue 10, p1855
Academic Journal
Phase-resolved optical Doppler tomography (ODT), an imaging technique based on low coherence interferometry, is presented as a tool to perform high-resolution cross-sectional imaging of fluidic flow in microchannels with high velocity sensitivity. To demonstrate ODT as a tool, electro-osmotic flow (EOF) was investigated, observing cross-sectional images of bidirectional flow within a microfluidic channel and pulsating flow when driven by a pulsed electrical field. ODT demonstrates great promise as a tool for studying the effects of microchannel surface modifications on biological sample flow and optimizing microfluidic device design.


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