TITLE

Dialysis-Chelex method for determination of exchangeable copper in human plasma

AUTHOR(S)
Venelinov, Tony I.; Davies, Ian M.; Beattie, John H.
PUB. DATE
July 2004
SOURCE
Analytical & Bioanalytical Chemistry;Jul2004, Vol. 379 Issue 5/6, p777
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A method based on dialysis in the presence of histidine, and subsequent copper adsorption and preconcentration using Chelex-100 resin, has been developed for selective extraction of exchangeable copper from blood plasma. The method was verified by comparative analysis using two different instrumental techniques, ICP-MS and AAS. The results obtained were in excellent agreement. Accurate quantification of the exchangeable copper and the firmly bound copper was achieved. The method was further validated by analysis of a lyophilised human serum certified reference material.
ACCESSION #
14387487

 

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