EVI1 induces myelodysplastic syndrome in mice
Tags: MYELODYSPLASTIC syndromes; MYELOID leukemia; APOPTOSIS; HEMATOPOIETIC stem cells; CHROMOSOMES; MICE as laboratory animals
Related Articles
- Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. Zhifu Xiang; Hui Luo; Payton, Jacqueline E.; Cain, Jennifer; Ley, Timothy J.; Opferman, Joseph T.; Tomasson, Michael H. // Journal of Clinical Investigation;Jun2010, Vol. 120 Issue 6, p2109
Antiapoptotic BCL2 family members have been implicated in the pathogenesis of acute myelogenous leukemia (AML), but the functional significance and relative importance of individual proteins (e.g., BCL2, BCL-XL, and myeloid cell leukemia 1 [MCL1]) remain poorly understood. Here, we examined the...
- DNA microarray analysis of hematopoietic stem cell-like fractions from individuals with the M2 subtype of acute myeloid leukemia. Oshima, Y.; Ueda, M.; Yamashita, Y.; Choi, Y.L.; Ota, J.; Ueno, S.; Ohki, R.; Koinuma, K.; Wda, T.; Ozawa, K.; Fujimura, A.; Mano, H. // Leukemia (08876924);Oct2003, Vol. 17 Issue 10, p1990
Acute myeloid leukemia (AML) may develop de novo or secondarily to myelodysplastic syndrome (MDS). Although the clinical outcome of MDS-related AML is worse than that of de novo AML, it is not easy to differentiate between these two clinical courses without a record of prior MDS. Large-scale...
- Chromosome 5q deletion and epigenetic suppression of the gene encoding a-catenin (CTNNA1) in myeloid cell transformation. Liu, Ting Xi; Becker, Michael W.; Jelinek, Jaroslav; Wu, Wen-Shu; Deng, Min; Mikhalkevich, Natallia; Hsu, Karl; Bloomfield, Clara D.; Stone, Richard M.; DeAngelo, Daniel J.; Galinsky, Ilene A.; Issa, Jean-Pierre; Clarke, Michael F.; Look, A. Thomas // Nature Medicine;Jan2007, Vol. 13 Issue 1, p78
Interstitial loss of all or part of the long arm of chromosome 5, or del(5q), is a frequent clonal chromosomal abnormality in human myelodysplastic syndrome (MDS, a preleukemic disorder) and acute myeloid leukemia (AML), and is thought to contribute to the pathogenesis of these diseases by...
- Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival. Gupta, P; Niehans, G A; LeRoy, S C; Gupta, K; Morrison, V A; Schultz, C; Knapp, D J; Kratzke, R A // Leukemia (08876924);Jan99, Vol. 13 Issue 1, p44
Increased apoptosis in the bone marrow (BM) may contribute to the cytopenias that occur in myelodysplastic syndromes (MDS). The Fas receptor, Fas ligand (FasL) pathway is a major mechanism of apoptosis. Since hematopoietic progenitors can express the Fas receptor, they may be susceptible to...
- Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Vassiliou, George S.; Cooper, Jonathan L.; Rad, Roland; Li, Juan; Rice, Stephen; Uren, Anthony; Rad, Lena; Ellis, Peter; Andrews, Rob; Banerjee, Ruby; Grove, Carolyn; Wei Wang; Liu, Pentao; Wright, Penny; Arends, Mark; Bradley, Allan // Nature Genetics;May2011, Vol. 43 Issue 5, p470
Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis whose largest subgroup is characterized by somatic mutations in NPM1, which encodes nucleophosmin. These mutations, termed NPM1c, result in cytoplasmic dislocation of nucleophosmin and are associated with...
- SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function. Hansen, N; Ågerstam, H; Wahlestedt, M; Landberg, N; Askmyr, M; Ehinger, M; Rissler, M; Lilljebjörn, H; Johnels, P; Ishiko, J; Melo, J V; Alexander, W S; Bryder, D; Järås, M; Fioretos, T // Leukemia (08876924);Jan2013, Vol. 27 Issue 1, p130
Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the...
- Leukemia stem cells. Testa, Ugo // Annals of Hematology;Mar2011, Vol. 90 Issue 3, p245
Leukemia-initiating cells (LICs) or leukemia stem cells (LSCs) are defined by their ability to form tumors after xenotransplantation in immunodeficient mice and appear to be rare in most human leukemias. In various leukemias, only small subpopulations of cells can transfer disease upon...
- Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells. Kustikova, O S; Schwarzer, A; Stahlhut, M; Brugman, M H; Neumann, T; Yang, M; Li, Z; Schambach, A; Heinz, N; Gerdes, S; Roeder, I; Ha, T C; Steinemann, D; Schlegelberger, B; Baum, C // Leukemia (08876924);May2013, Vol. 27 Issue 5, p1127
The transcription factor Evi1 has an outstanding role in the formation and transformation of hematopoietic cells. Its activation by chromosomal rearrangement induces a myelodysplastic syndrome with progression to acute myeloid leukemia of poor prognosis. Similarly, retroviral insertion-mediated...
- Activated natural killer cells from patients with acute myeloid leukemia are cytotoxic against autologous leukemic blasts in NOD/SCID mice. Siegler, U.; Kalberer, C.P.; Nowbakht, P.; Sendelov, S.; Meyer-Monard, S.; Wodnar-Filipowicz, A. // Leukemia (08876924);Dec2005, Vol. 19 Issue 12, p2215
Natural killer (NK) cells are implicated in the surveillance of hematological malignancies. They participate in the immune response against residual acute myeloid leukemia (AML) after hematopoietic stem cell transplantation with partial HLA class I disparity. However, the role of NK cells in...
