Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus

Holers, V. Michael
September 2004
Journal of Clinical Investigation;Sep2004, Vol. 114 Issue 5, p616
Academic Journal
Patients with systemic lupus erythematosus (SLE) often develop glomerulonephritis (i.e., inflammation in the glomeruli of the kidney), commonly referred to as lupus nephritis. Patients with lupus nephritis typically have autoantibodies to the complement classical pathway protein C1q. Whether these anti-C1q antibodies play any role in the development of lupus nephritis has been unclear. In this issue of the JCI, a new study demonstrates that anti-C1q antibodies can amplify glomerular injury but only when they are bound within the glomerulus to C1q that has been already brought to that site by other types of glomerular-reactive autoantibodies. These studies are the first, to our knowledge, to provide a causal link between anti-C1q antibodies and target organ damage in SLE.


Related Articles

  • Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers. Akhter, E; Burlingame, RW; Seaman, AL; Magder, L; Petri, M // Lupus;Dec2011, Vol. 20 Issue 12, p1267 

    Objective. Autoantibodies are important in the diagnosis and classification of systemic lupus erythematosus (SLE), but whether they correlate with changes in disease activity within individual patients is controversial. We assessed the association between changes in SLE global and renal activity...

  • A study on anti-mannose binding lectin (anti-MBL) antibodies and serum MBL levels in Indian systemic lupus erythematosus patients. Pradhan, Vandana; Mahant, Gauri; Rajadhyaksha, Anjali; Surve, Prathamesh; Rajendran, Vinod; Patwardhan, Manisha; Nadkarni, Anita; Dighe, Shruti; Ghosh, Kanjaksha // Rheumatology International;May2013, Vol. 33 Issue 5, p1193 

    Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by systemic inflammation and autoantibody production. Anti-mannose binding lectin (anti-MBL) autoantibodies have been studied in SLE for their possible effect on mannose binding lectin (MBL) levels and functional...

  • Clinical and diagnostic value of ribosomal P autoantibodies in systemic lupus erythematosus. Haddouk, Samy; Marzouk, Sameh; Jallouli, Moez; Fourati, Hajer; Frigui, Makram; Hmida, Youssef B. H.; Koubaa, Faten; Sellami, Wassim; Baklouti, Sofiene; Hachicha, Jamil; Bahloul, Zouheir; Masmoudi, Hatem // Rheumatology;Aug2009, Vol. 48 Issue 8, p953 

    Objective. To analyse prospectively the diagnostic sensitivity and specificity as well as the clinical relevance of ribosomal P (anti-P) autoantibodies in a large cohort of SLE patients.

  • Circulating antibodies to guanosine in systemic lupus erythematosus: correlation with nephritis and polyserositis by acute and longitudinal analyses. Colburn, K.; Green, L.; Wong, A. // Lupus;Jun2001, Vol. 10 Issue 6, p410 

    Systemic lupus erythematosus (SLE) is characterized by autoantibodies, including antibodies to the nucleosides of DNA. Guanosine is the most immunogenic nucleoside. In this study serum antiguanosine antibody levels were compared with disease activity, determined by their SLEDI score, in 86...

  • Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles, Nicolas; Hardwick, Donna; Daugas, Eric; Illei, Gabor G.; Rivera, Juan // Nature Medicine;Jun2010, Vol. 16 Issue 6, p701 

    In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their homing to lymph nodes, promoting T helper type 2 (TH2) cell...

  • Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis. Sui, Mansu; Lin, Qingyuan; Xu, Zhaozhen; Han, Xiaojing; Xie, Rujuan; Jia, Xiuzhi; Guo, Xiaofang; Zhang, Weihua; Guan, Xiuru; Ren, Huan // Journal of Clinical Immunology;Feb2013, Vol. 33 Issue 2, p378 

    Objective: The purpose of this study is to examine autoantibody profile of systemic lupus erythematosus (SLE) patients with lupus nephritis (LN) and to establish the correlation between the antibody reactivity and disease activity of LN. Methods: Autoantibodies and serological parameters were...

  • Pathogenic autoantibodies in lupus nephritis. Waldman, M.; Madaio, M. P. // Lupus;2005, Vol. 14 Issue 1, p19 

    Lupus nephritis is a major complication of systemic lupus erythematosus (SLE) and is associated with a high rate of morbidity and mortality. While many different immunologic and nonimmunologic factors contribute to disease expression in lupus nephritis, a large body of evidence suggests that the...

  • Lupus-Update on the Treatment of Systemic Lupus. Vinall, Maria // MD Conference Express;Dec2012, p25 

    The article offers information the treatment for systemic lupus erythematosus (SLE). It states that treatment for SLE can be found in classification and available treatments for variants of cutaneous lupus erythematous (CLE). It mentions that for the classification of SLE, the patient must...

  • Association of serum uric acid with lupus nephritis in systemic lupus erythematosus. Zaixing Yang; Yan Liang; Weihua Xi; Ye Zhu; Chang Li; Renqian Zhong // Rheumatology International;Jun2011, Vol. 31 Issue 6, p743 

    The aim of the present study is to assess the association of elevated serum uric acid (UA) with lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients. A total of 130 SLE patients were recruited, of whom 73 patients developed LN. Blood samples were obtained for determination of uric...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics