TITLE

Poly(dimethylsiloxane) microchip capillary electrophoresis with electrochemical detection for rapid measurement of acetaminophen and its hydrolysate

AUTHOR(S)
He, F.V.; Liu, A.L.; Xia, X.H.
PUB. DATE
August 2004
SOURCE
Analytical & Bioanalytical Chemistry;Aug2004, Vol. 379 Issue 7/8, p1062
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Poly(dimethylsiloxane) microchip capillary electrophoresis with amperometric detection has been used for rapid separation and determination of acetaminophen and its hydrolysate, i.e. p-aminophenol. A Pt ultramicroelectrode with a diameter of 10 µm positioned at the outlet of the separation channel was used as a working electrode for amperometric detection. Factors influencing separation and detection were investigated and optimized. Results show that acetaminophen and p-aminophenol can be well separated within 35 s with RSD-1 (approximately 0.1 µmol) at S/N= 3. This method has been successfully applied to the detection of traces of p-aminophenol in paracetamol tablets.
ACCESSION #
14281867

 

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