TITLE

Direct determination of trace refractory elements in human serum by ETV–ICP–MS with in-situ matrix removal

AUTHOR(S)
Shengqing Li; Bin Hu; Zucheng Jiang; Rui Chen
PUB. DATE
August 2004
SOURCE
Analytical & Bioanalytical Chemistry;Aug2004, Vol. 379 Issue 7/8, p1076
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A method for in-situ removal of matrix is proposed for direct determination of trace refractory elements in human serum by ETV-ICP-MS with the use of poly(tetrafluoroethylene) (PTFE) as fluorinating re-agent. Attention has been paid to investigating the vaporization behavior both of refractory elements of interest and of matrix elements (Na, K, Ca, Mg, Cl, S, and P) in a graphite furnace with the PTFE modifier present or not. It was shown that potential interferences from the organic and inorganic matrices in the serum sample could be eliminated or reduced to a negligible level by appropriate dilution of the serum and deliberate optimization of the ETV temperature program. The proposed method has been applied to the direct simultaneous determination of V, Crk, Mo, Ba, La, Ce, and W in human serum. The limits of detection for fivefold diluted serum were 0.18 (V), 0.229 (Crk), 0.050 (Mo), 0.328 (Ba), 0.031 (La), 0.038 (Ce), and 0.019 ng mL-1 (W), respectively, and the relative standard deviations of the method were in the range 4-15% (2 ng mL-1 in serum, n = 3).
ACCESSION #
14281863

 

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