TITLE

Determination of the MRI contrast agent Gd-DTPA by SEC–ICP–MS

AUTHOR(S)
Loreti, Valeria; Bettmer, Jörg
PUB. DATE
August 2004
SOURCE
Analytical & Bioanalytical Chemistry;Aug2004, Vol. 379 Issue 7/8, p1050
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The simultaneous determination of Gd3+ and Gd-DTPA (DTPA: diethylenetriamino-pentaacetic acid), often used as contrast agent, is described. The proposed approach combines size-exclusion chromatography (SEC) and inductively coupled plasma-mass spectrometry (ICP-MS) for element-selective detection in order to determine also high-molecular Gd-complexes if present. This method was applied to the analysis of urine samples of a patient to whom Gd-DTPA was intravenously administered. The results showed that no conversion or adsorption of Gd-DTPA could be observed in any sample, even free Gd3+ could not be detected. Urine excretion behaviour was monitored and it was proved that Gd-DTPA was almost completely (>99%) excreted by urination within one day. Traces of Gd-DTPA could be measured in hair samples, but extraction with tetramethylammonium hydroxide (TMAH) resulted in degradation of Gd-DTPA.
ACCESSION #
14281856

 

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