Recommended diagnostic criteria for paraneoplastic neurological syndromes

Greenlee, J. E.
August 2004
Journal of Neurology, Neurosurgery & Psychiatry;Aug2004, Vol. 75 Issue 8, p1090
Academic Journal
This article focuses on recommended diagnostic criteria for paraneoplastic neurological syndromes. Paraneoplastic neurological syndromes are remote complications of systemic malignancy, characterized clinically by subacute progression to profound neurological disability and pathologically by destruction of neurones, with or without an accompanying inflammatory response. The major paraneoplastic neurological syndromes had been largely categorized by 1965, and this same categorization is still used for diagnosis today, supported by detection of antineuronal autoantibodies.


Related Articles

  • Which antibody and which cancer in which paraneoplastic syndromes? Gozzard, Paul; Maddison, Paul // Practical Neurology (BMJ Publishing Group);Oct2010, Vol. 10 Issue 5, p260 

    Paraneoplastic neurological syndromes can be associated with the presence of onconeural antibodies. These antibodies are the result of an immune response against a tumour that is ectopically expressing a neuronal antigen. The ‘classical’ onconeural antibodies (anti-Hu, Yo, Ma2,...

  • Neuromuscular Paraneoplastic Syndromes: The Lambert-Eaton Myasthenic Syndrome. Prommer, Eric // Journal of Palliative Medicine;Sep2010, Vol. 13 Issue 9, p1159 

    Background: Disorders in which the effects of cancer occur at a site remote from the primary tumor are termed paraneoplastic disorders. The most well- known paraneoplastic disorder affecting the neuromuscular junction is the Lambert-Eaton myasthenic syndrome (LEMS). Discussion: We describe a...

  • Paraneoplastic cerebellar ataxia and the paraneoplastic syndromes. Afzal, Sadaf; Recio, Maria; Shamim, Sadat // Baylor University Medical Center Proceedings;Apr2015, Vol. 28 Issue 2, p217 

    Paraneoplastic cerebellar ataxia, also known as paraneoplastic cerebellar degeneration, is one of the wide array of paraneoplastic neurological syndromes in which neurological symptoms are indirectly caused by an underlying malignancy, most commonly gynecological, breast, or lung cancer or...

  • Anti-Ma and anti-TA associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases. Hoffman, L. A.; Jarius, S.; Pellkofer, H. L.; Schueeler, M.; Krumbholz, M.; Koenig, F.; Johannis, W.; la Fougere, C.; Newman, T.; Vincent, A.; Voltz, R. // Journal of Neurology, Neurosurgery & Psychiatry;Jul2008, Vol. 79 Issue 7, p767 

    Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with the presence of specific serum antibodies. The most recently described PNS defining reactivity is anti-Ma/anti-Ta. Here we present 22 newly diagnosed...

  • Hypertrophic Osteoarthropathy as a Clinical Manifestation of Lung Cancer. Davis, Melissa C.; Sherry, Victoria // Clinical Journal of Oncology Nursing;Oct2011, Vol. 15 Issue 5, p561 

    Hypertrophic osteoarthropathy is a paraneoplastic syndrome most often found in non-small cell lung cancer. Diagnosis is confirmed by the presence of clubbing on physical examination and periostitis on bone scintigram, and the syndrome generally resolves with treatment of the underlying...

  • Recommended diagnostic criteria for paraneoplastic neurological syndromes. Graus, F.; Delattre, J. Y.; Antoine, J. C.; Dalmau, J.; Giometto, B.; Grisold, W.; Honnorat, J.; Smitt, P. Sillevis; Vedeler, Ch.; Verschuuren, J. J. G. M.; Vincent, A.; Voltz, R. // Journal of Neurology, Neurosurgery & Psychiatry;Aug2004, Vol. 75 Issue 8, p1135 

    Background: Paraneoplastic neurological syndromes (PNS) are defined by the presence of cancer and exclusion of other known causes of the neurological symptoms, but this criterion does not separate "true" PNS from neurological syndromes that are coincidental with a cancer. Objective: To provide...

  • Paraneoplastic neurologic syndrome: A practical approach. Kannoth, Sudheeran // Annals of Indian Academy of Neurology;Jan2012, Vol. 15 Issue 1, p6 

    Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer, not caused by direct invasion, metastasis or consequences of treatment. They are usually autoimmune in nature. Often, PNS precedes the manifestations of cancer. Onconeural antibodies are important in the...

  • Avidity of onconeural antibodies is of clinical relevance. Totland, Cecilie; Ying, Ming; Haugen, Mette; Mazengia, Kibret; Storstein, Anette; Aarseth, Jan; Martinez, Aurora; Vedeler, Christian // Cancer Immunology, Immunotherapy;Aug2013, Vol. 62 Issue 8, p1393 

    Onconeural antibodies are important in the detection of paraneoplastic neurological syndromes (PNS). The avidity of Hu, Yo, and CRMP5 antibodies from 100 patients was determined by immunoprecipitation (IP), and 13 of the Yo positive sera were also tested by surface plasmon resonance (SPR). There...

  • Paraneoplastic limbic encephalitis associated with ovarian teratoma. LEE, KIAN-GUAN // Clinical Medicine;Feb2012, Vol. 12 Issue 1, p95 

    No abstract available.


Read the Article


Sign out of this library

Other Topics