TITLE

The Physiology of Nitric Oxide: Control and Consequences

AUTHOR(S)
Fleming, Ingrid; Busse, Rudi
PUB. DATE
September 2004
SOURCE
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Sep2004, Vol. 3 Issue 3, p189
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Since its recognition as an endothelium-derived relaxing factor, the control and consequences of nitric oxide (NO) production has been investigated intensely. NO is not simply a vasodilator or regulator of smooth muscle tone but is a potent anti-platelet agent, neuromodulator and regulator of gene expression. This article reviews the mechanisms (intracellular Ca2+, phosphorylation and protein-protein interaction) that regulate the activity of each of the NO synthase isoforms and describes the physiology of NO in the circulation, kidney, skeletal muscle as well as in endocrine, immune and nervous systems.
ACCESSION #
14259719

 

Related Articles

  • Physiology and pathophysiology of nitric oxide. Ignarro, Louis J. // Kidney International;Jun1996 Supplement, Vol. 49, pS2 

    Nitric oxide (NO) was discovered to be a potent vasodilator, inhibitor of platelet aggregation, and active species of nitroglycerin before the discovery of endothelium- derived relaxing factor (EDRF) in 1980. Subsequent studies revealed that EDRF is NO, and is synthesized by mammalian cells from...

  • The Many Antithrombotic Actions of Nitric Oxide. Tziros, Constantine; Freedman, Jane E. // Current Drug Targets;Oct2006, Vol. 7 Issue 10, p1243 

    Vessel occlusion within a coronary artery is the precipitating event in unstable coronary syndromes and is primarily due to rupture of atheromatous plaque and subsequent thrombus formation. In the nondiseased vessel, the intact endothelium releases the vasodilator and antithrombotic agent nitric...

  • Physiological importance of nitric oxide. Colliek, Joe // BMJ: British Medical Journal (International Edition);6/1/91, Vol. 302 Issue 6788, p1289 

    Examines the physiological importance of nitric oxide. Synthesis of nitric oxide from L-arginine by the vascular endothelium; Biological activity of the vasodilator endothelium derived relaxing factor; Actions of endothelium derived nitric oxide within the circulation.

  • Endothelial cell-derived nitric oxide mobilization is attenuated in copper-deficient rats. Falcone, Jeff C.; Lominadze, David; Johnson, W. Thomas; Schuschke, Dale A. // Applied Physiology, Nutrition & Metabolism;Dec2008, Vol. 33 Issue 6, p1073 

    The attenuation of endothelium-dependent nitric oxide (NO) mediated vasodilation is a consistent finding in both conduit and resistance vessels during dietary copper (Cu) deficiency. Although the effect is well established, evidence for the mechanism remains circumstantial. This study was...

  • Calcium Imaging of Murine Thoracic Aorta Endothelium by Confocal Microscopy Reveals Inhomogeneous Distribution of Endothelial Cells Responding to Vasodilator Agents. Marie, Isabelle; Bény, Jean-Louis // Journal of Vascular Research;2002, Vol. 39 Issue 3, p260 

    The aim of the study was to assess, in intact murine thoracic aorta in vitro, the distribution of endothelial cells responsive to endothelium-dependent vasodilators ACh, ATP, bradykinin and substance P, using laser line confocal microscopy in combination with two Ca[sup 2+] fluorescent dyes,...

  • Alteration of Decreased Plasma NO Metabolites and Platelet NO Synthase Activity by Paroxetine in Depressed Patients. Chrapko, Wendy; Jurasz, Paul; Radomski, Marek W.; Archer, Stephen L.; Newman, Stephen C.; Baker, Glen; Lara, Nathalie; Le Mellédo, Jean-Michel // Neuropsychopharmacology;Jun2006, Vol. 31 Issue 6, p1286 

    Although major depression (MD) and cardiovascular disease (CVD) have been conclusively linked in the literature, the mechanism associating MD and CVD is yet undetermined. The purpose of this paper is to further investigate a potential mechanism involving nitric oxide (NO) and to examine the...

  • Renal and systemic nitric oxide synthesis in rats with renal mass reduction. Aiello, Sistiana; Noris, Marina; Todeschini, Marta; Zappella, Sergio; Foglieni, Chiara; Benigni, Ariela; Corna, Daniela; Zoja, Carla; Cavallotti, Daniela; Remuzzi, Giuseppe // Kidney International;Jul1997, Vol. 52 Issue 1, p171 

    The article presents information on renal and systemic nitric oxide synthesis in rats with renal mass reduction. Nitric-oxide (NO), an L-arginine derivative, is implicated in neuronal transmission, immune response and vasodilation, beside acting as a platelet function modulator. The conversion...

  • Nitric oxide: considerations for the treatment of ischemic stroke. Terpolilli, Nicole A; Moskowitz, Michael A; Plesnila, Nikolaus // Journal of Cerebral Blood Flow & Metabolism;Jul2012, Vol. 32 Issue 7, p1332 

    Some 40 years ago it was recognized by Furchgott and colleagues that the endothelium releases a vasodilator, endothelium-derived relaxing factor (EDRF). Later on, several groups identified EDRF to be a gas, nitric oxide (NO). Since then, NO was identified as one of the most versatile and unique...

  • Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery. Quinn, S; O'Brien, C; McLoughlin, P // Eye;Jul2003, Vol. 17 Issue 5, p628 

    Purpose: Vascular endothelial cell dysfunction has been noted in patients with normal pressure glaucoma. Although nitric oxide (NO) accounts for a large proportion of vasorelaxation in the posterior ciliary artery, considerable relaxation remains unexplained. We investigated the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics