Renal and systemic nitric oxide synthesis in rats with renal mass reduction

Aiello, Sistiana; Noris, Marina; Todeschini, Marta; Zappella, Sergio; Foglieni, Chiara; Benigni, Ariela; Corna, Daniela; Zoja, Carla; Cavallotti, Daniela; Remuzzi, Giuseppe
July 1997
Kidney International;Jul1997, Vol. 52 Issue 1, p171
Academic Journal
The article presents information on renal and systemic nitric oxide synthesis in rats with renal mass reduction. Nitric-oxide (NO), an L-arginine derivative, is implicated in neuronal transmission, immune response and vasodilation, beside acting as a platelet function modulator. The conversion of L-arginine to L-citrulline that leads to the formation of NO is catalyzed by a family of NO synthase (NOS) enzymes that exists in at least three distict isoforms, neuronal NOS, inducible NOS and endothelial NOS.


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