TITLE

Breakthrough Fungal Infections in Stem Cell Transplant Recipients Receiving Voriconazole

AUTHOR(S)
Imhof, Alexander; Balajee, S. Arunmozhi; Fredricks, David N.; Englund, Janet A.; Marr, Kieren A.
PUB. DATE
September 2004
SOURCE
Clinical Infectious Diseases;9/1/2004, Vol. 39 Issue 5, p743
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Infection with voriconazole-resistant fungi may become problematic, because organisms with decreased susceptibility have been noted. Breakthrough fungal infections occurred in 13 of 139 patients who received voriconazole at our center during the period of September 1998 through September 2003. Zygomycetes were found in 6 patients, and Candida glabrata bloodstream infection occurred in 4 patients. Minimal inhibitory concentrations were ⩾1 μg/mL for all avail- able isolates. Yeasts and molds with decreased susceptibility to voriconazole may cause invasive infection in patients treated successfully for aspergillosis.
ACCESSION #
14174314

 

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