TITLE

The Effects of Low-Dose Growth Hormone in HIV-Infected Men with Fat Accumulation: A Pilot Study

AUTHOR(S)
Lo, Joan C.; Mulligan, Kathleen; Noor, Mustafa A.; Lee, Grace A.; Schwarz, Jean-Marc; Grunfeld, Carl; Schambelan, Morris
PUB. DATE
September 2004
SOURCE
Clinical Infectious Diseases;9/1/2004, Vol. 39 Issue 5, p732
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pharmacologic doses of growth hormone (GH) reduce HIV- associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.
ACCESSION #
14174297

 

Related Articles

  • Effect of Several Plants' Active Ingredients on Glucose Metabolism in Rat Adipocytes. WANG Jie-si; ZHANG Wen; SHI Chang-jie; LI Jia-gui; GUO Xiao-li; QU Wei-jing // Natural Product Research & Development;Dec2009, Vol. 21 Issue 6, p1015 

    To observe the effect of several plants' active ingredients on glucose metabolism in rat adipocytes by glucose consumption assay. The results showed that the glucose consumptions of rat adipocytes were significantly increased by 10-4-1 U/mL insulin; 100-1000 µg/mL FSH and 1000 µg/mL FRRT...

  • Type 2 diabetes: Personalizing therapy. Crunkhorn, Sarah // Nature Reviews Drug Discovery;Dec2014, Vol. 13 Issue 12, p888 

    The article discusses the use of mice in overexpressing the glucose transporter Glut4 in adipocytes that advance lipogenesis and increased glucose tolerance of fatty acid in hydroxy fatty acids (FAHFA) in adipose tissue.

  • Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability. Sabater, David; Arriarán, Sofía; del Mar Romero, María; Agnelli, Silvia; Remesar, Xavier; Fernández-López, José Antonio; Alemany, Marià // Scientific Reports;1/17/2014, p1 

    White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to...

  • Cortisol and growth hormone responses to spontaneous hypoglycaemia in infants and children. Crofton, P. M.; Midgley, P. C. // Archives of Disease in Childhood;May2004, Vol. 89 Issue 5, p472 

    Aims: To evaluate responses of cortisol and growth hormone (GH) to spontaneous hypoglycaemia in infants and children. Methods: Retrospective review of laboratory and clinical data in paediatric patients investigated for suspected hypoglycaemia over a five year period. Thirty patients (16 aged <...

  • Effects of triiodothyronine and bovine growth hormone on glucose transporter isoform-2 (GLUT-2) and glucokinase (GK) gene expression in pancreatic islets of fetal and adult rats. García-Flores, Marta; Blázquez, Enrique; Zueco, José A. // Pflugers Archiv European Journal of Physiology;Aug2001, Vol. 442 Issue 5, p662 

    This study was conducted to determine the effects of triiodothyronine (T3) and bovine growth hormone (bGH) on the expression of glucose transporter-2 (GLUT-2) and of glucokinase (GK) from pancreatic islets of fetal and adult rats. Incubation of both sets of pancreatic islets with T3 did not...

  • Growth hormone reduced HIV-related visceral fat.  // Endocrine Today;11/10/2008, Vol. 6 Issue 20, p10 

    The article discusses a study of the effectiveness of low-dose growth hormone (GH) in reducing visceral fat and truncal obesity related to HIV, which was published in the 2008 issue of the "Journal of the American Medical Association." It showed decreased visceral adipose tissue, trunk fat,...

  • Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes. Yuchao Zhang; Yuantao Liu; Xia Li; Weina Gao; Wenjie Zhang; Qingbo Guan; Jing Jiang; Frank, Stuart J.; Xiangdong Wang // Lipids in Health & Disease;2013, Vol. 12 Issue 1, p1 

    Background: Growth hormone (GH) and insulin signaling pathways are known important regulators of adipose homeostasis. The cross-talk between GH and insulin signaling pathways in mature adipocytes is poorly understood. Methods: In the present study, the impact of insulin on GH-mediated signaling...

  • Decrease of subcutaneous adipose tissue lipolysis after exposure to hypoxia during a simulated ascent of Mt Everest. de Glisezinski, Isabelle; Crampes, François; Harant, Isabelle; Havlik, Patrick; Gardette, Bernard; Jammes, Yves; Souberbielle, Jean-Claude; Richalet, Jean-Paul; Rivvère, Daniel // Pflugers Archiv European Journal of Physiology;Jan2000, Vol. 439 Issue 1/2, p134 

    The purpose of this study was to examine the effects of prolonged hypoxia on adipose tissue lipolysis, in relation to the weight loss usually observed at high altitude. Eight male subjects were exposed for 31 days to gradually increasing hypobaric hypoxia up to the equivalent altitude of 8848 m...

  • Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). Kichoon Lee; Villena, Josep A.; Yang Soo Moon; Kee-Hong Kim; Sunjoo Lee; Chulho Kang; Hei Sook Sul // Journal of Clinical Investigation;2/15/2003, Vol. 111 Issue 4, p453 

    Focuses on a study which demonstrated inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 using transgenic mice. Methods; Results and discussion; Conclusion.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics