Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management

Lim, Sue; Katz, Kevin; Krajden, Sigmund; Fuksa, Milan; Keystone, Jay S.; Kain, Kevin C.
August 2004
CMAJ: Canadian Medical Association Journal;8/31/2004, Vol. 171 Issue 5, p479
Academic Journal
STRONGYLOIDIASIS, WHICH IS CAUSED by the nematode Strongyloides stercoralis, is a common and persistent infection, particularly in developing countries. In the setting of compromised cellular immunity, it can result in fulminant dissemination with case-fatality rates of over 70%. The majority of new Canadian immigrants come from countries where Strongyloides is highly endemic; therefore, the burden of Strongyloides may be underappreciated in Canada. Because early diagnosis and therapy can have a marked impact on disease outcome, screening for this infection should be considered mandatory for patients who have a history of travel or residence in a disease-endemic area and risk factors for disseminated disease (e.g., corticosteroid use and human T-lymphotropic virus type I infection).


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