TITLE

Various parameters in the preparation of chitosan/polyethylene oxide electrospun nanofibers containing Aloe vera extract for medical applications

AUTHOR(S)
Nikbakht, Mohammad; Salehi, Majid; Rezayat, Seyed Mahdi; Majidi, Reza Faridi
PUB. DATE
January 2020
SOURCE
Nanomedicine Journal;Winter2020, Vol. 7 Issue 1, p21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective(s): The present study aimed to fabricate chitosan/polyethylene oxide (CS/PEO) electrospun nanofibers loaded with Aloe vera extract for biomedical applications. The polymer-to-extract ratio and electrospinning parameters (applied voltage and nozzle-to-collector distance) were evaluated in order to optimize the process of nanofiber fabrication. Materials and Methods: The characterizations were performed using scanning electron microscopy (SEM), ImageJ software, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), tensile strength test, and UV-Vis spectroscopy. Results: The obtained results indicated that the fabrication of nanofibers from pure Aloe vera extract was unsuccessful, and reducing the extract concentration from 100% to 92% resulted in the formation of the nanofibers. Moreover, further reduction in the extract from 92% to 50% led to the production of fine nanofibers (mean diameters: 204±42 and 398±51 nm, respectively). Therefore, it was concluded that the reduced concentration of the herbal extract increased the diameters of the prepared nanofibers. In addition, the results of the optimization process indicated a direct correlation between the applied voltage and nanofiber diameters, as well as an inverse correlation between the nozzle-to-collector distance and nanofiber diameters. The FTIR spectroscopy also confirmed the presence of CS, PEO, and Aloe vera in the final prepared scaffold. The release measurement revealed a burst effect within the first five hours, followed by a sustain release within 30 hours. Moreover, the biocompatibility assay confirmed the proliferative potential of Aloe vera within seven days. Conclusion: According to the results, a nanofibrous scaffold composed of CS and PEO could be fabricated as the carrier of Aloe vera extract, which is a suitable platform for biomedical applications.
ACCESSION #
141655236

 

Related Articles

  • THE MIGRATION OF SURFACTANTS IN ACRYLIC EMULSION PAINT FILMS. Digney-Peer, Shawn; Bumstock, Aviva; Leamer, Tom; Khanjian, Herant; Hoogland, Frank; Boon, Jaap // Studies in Conservation;2004 Supplement, Vol. 49, p202 

    Artists' acrylic emulsion paints are formulated using many constituents. Non-ionic surfactants such as those based on polyethylene oxides (PEOs) have been found in acrylic paint films, which may function both to stabilize the acrylic polymer in the aqueous emulsion phase and to aid pigment...

  • Near-Infrared Spectroscopy Speeds Sample Identification.  // R&D Magazine;Sep2001, Vol. 43 Issue 9, p37 

    Introduces the Antaris Near-IR Analyzer, a Fourier transform near infrared (NIR) portable unit developed by a team of researchers at ThermoNicolet company. Uses; How the equipment works; Information on NIR light.

  • Experimental technique using FTIR to estimate IR optical properties at variable temperatures: Application to PMDA-ODA polyimide thin films from 100 to 380 °C. Chandrasekharan, Ramesh; Masel, Richard I.; Shannon, Mark A. // Review of Scientific Instruments;May2007, Vol. 78 Issue 5, p053105 

    An experimental technique is presented to measure reflectance at high sample temperature with respect to room temperature in the infrared using Fourier transform infrared fitted with a reflectometer. Sample temperature artifacts are accounted for by sequential measurements taken with the lamp...

  • An ion-imprinted polymer for the selective extraction of mercury(II) ions in aqueous media. Batlokwa, Bareki S.; Chimuka, Luke; Tshentu, Zenixole; Cukrowska, Ewa; Torto, Nelson // Water SA;Apr2012, Vol. 38 Issue 2, p255 

    A double-imprinted polymer exhibiting high sensitivity for mercury(II) in aqueous solution is presented. Polymer particles imprinted with mercury(II) were synthesised by copolymerising the functional and cross-linking monomers, N'-[3- (Trimethoxysilyl)-propyl]diethylenetriamine (TPET) and...

  • Preparation of a boronate-functionalized affinity hybrid monolith for specific capture of glycoproteins. Yang, F.; Mao, J.; He, X.; Chen, L.; Zhang, Y. // Analytical & Bioanalytical Chemistry;Jun2013, Vol. 405 Issue 15, p5321 

    A novel strategy for preparation of a boronate affinity hybrid monolith was developed using a Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) reaction of an alkyne-boronate ligand with an azide-functionalized monolithic intermediate. An azide-functionalized hybrid monolith was...

  • Polymethylmethacrylate/Fe3O4 composite nanofiber membranes with ultra-low dielectric permittivity. Zhang, C. C.; Li, X.; Yang, Y.; Wang, C. // Applied Physics A: Materials Science & Processing;Nov2009, Vol. 97 Issue 2, p281 

    Ultra-low dielectric permittivity poly (methyl methacrylate)/Fe3O4 composite fiber membranes have been successfully prepared using electrospinning. The composite membranes were characterized by SEM (scanning electron microscopy), TEM (transmission electron microscopy), FT-IR (Fourier transform...

  • Statistical Modelling Optimisation of Cellulase Enzyme Immobilisation on Functionalised Multi-Walled Carbon Nanotubes for Empty Fruit Bunches Degradation. Alkhatib, Ma'an F.; Alam, M. d. Zahangir; Mohammed, Rasha // Australian Journal of Basic & Applied Sciences;Jan2012, Vol. 6 Issue 1, p30 

    Cellulase obtained from the fermentation of sewage treatment plant sludge (STP) by Trichoderma-reesei RUT C-30 was covalently immobilised on functionalised multi-wall carbon nanotubes. Statistical optimisation using the Plackett-Burman design method was implemented to identify parameters with...

  • Characterization of Water Extractable Arabinoxylans from a Spring Wheat Flour: Rheological Properties and Microstructure. Morales-Ortega, Adriana; Carvajal-Millan, Elizabeth; López-Franco, Yolanda; Rascón-Chu, Agustín; Lizardi-Mendoza, Jaime; Torres-Chavez, Patricia; Campa-Mada, Alma // Molecules;Jul2013, Vol. 18 Issue 7, p8417 

    In the present study water extractable arabinoxylans (WEAX) from a Mexican spring wheat flour (cv. Tacupeto F2001) were isolated, characterized and gelled and the gel rheological properties and microstructure were investigated. These WEAX presented an arabinose to xylose ratio of 0.66, a ferulic...

  • Equilibrium and kinetic studies of fluoride adsorption by chitosan coated perlite. Vijaya, Y.; Subbaiah, M. Venkata; Reddy, A. Subba; Krishnaiah, A. // Desalination & Water Treatment;Aug2010, Vol. 20 Issue 1-3, p272 

    A new biosorbent was developed by coating chitosan, a naturally and abundantly available biopolymer, on to perlite. The surface morphology of chitosan coated perlite (CCP) was observed using scanning electron microscopic (SEM) studies. Fourier transform infrared spectroscopy (FTIR) was used for...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics