TITLE

Dolutegravir early during pregnancy linked with neural tube defects

PUB. DATE
February 2020
SOURCE
Reactions Weekly;2/8/2020, Vol. 1790 Issue 1, p1
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
Medicine information for dolutegravir-containing products in New Zealand (NZ) now includes the possible increased risk of neural tube defects when taken early during pregnancy, says Medsafe. The risks and benefits of continuing dolutegravir versus switching to another antiretroviral regimen (or switching to an alternative regimen) should be assessed in WOCBP who are actively seeking to become pregnant, or if pregnancy is confirmed within the first trimester while receiving dolutegravir; The sponsor of dolutegravir has written to healthcare professionals to provide further information about this safety issue, and the consumer medicine information and data sheets have also been updated.
ACCESSION #
141597673

 

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