Lower serum nicotinamide N-methyltransferase levels in patients with bipolar disorder during acute episodes compared to healthy controls: a cross-sectional study

Hu, Qing; Liu, Farong; Yang, Luyin; Fang, Zanxi; He, Jue; Wang, Wenqiang; You, Pan
January 2020
BMC Psychiatry;1/30/2020, Vol. 20 Issue 1, p1
Academic Journal
Background: Nicotinamide N-methyltransferase (NNMT) has been implicated in the pathogenesis of neuropsychiatric diseases. Bipolar disorder (BD) is associated with metabolic abnormalities and NNMT regulates energy metabolism and may also exert a causal role in metabolic disorders. The present study aimed to determine serum NNMT levels in patients with BD and compared the results with that of healthy controls, to explore the correlation between NNMT and clinical and metabolic characteristics. Methods: The NNMT levels of 80 patients having a manic episode of BD and 65 non-psychiatric control individuals were measured using enzyme-linked immunosorbent assay. Metabolic parameters were evaluated using standard laboratory methods. Results: The serum NNMT levels of bipolar mania patients were significantly lower than that of non-psychiatric controls. Furthermore, the serum levels of NNMT were found to be negatively correlated with Young Mania Rating Scale (YMRS) scores and the duration of the illness. Moreover, lower NNMT serum levels were found in patients with a history of antipsychotic medication and dyslipidemia. Our results also demonstrated the different patterns of correlation that exist between the study groups. Serum NNMT levels were found to be negatively correlated with triglyceride, cholesterol, and apolipoprotein B levels in the BD group, while the same was found to be negatively associated only with high-density lipoprotein cholesterol in the control group. Conclusions: These findings support the suggestion that lower NNMT serum levels are significantly associated with BD and that serum NNMT has the potential to regulate lipid metabolism in BD patients.


Related Articles

  • Correlation between the level of cholesteryl ester transfer protein in follicular fluid with fertilization rates in IVF/ICSI cycles. Mehdizadeh, Amir; Rahimipour, Ali; Farzadi, Laya; Darabi, Masoud; Shahnazi, Vahideh; Shaake, Maghsod; Vaiankhah, Amir-Mansour; Golmohamadi, Zahra; Nouri, Mohammad // Iranian Journal of Reproductive Medicine;Summer2011, Vol. 9 Issue 3, p193 

    Background: Follicular fluid (FF) plays an important role in oocytes and embryo development, which may contribute to IVF/ICSI success rate. Objective: The aim of this study was to investigate the correlation between cholesteryl ester transfer protein (CETP) level in FF and the success rate of...

  • LIPID PROFILE ABNORMALITIES IN HYPOTHYROIDISM. Shashi, A.; Sharma, N. // International Journal of Science & Nature;2012, Vol. 3 Issue 2, p354 

    The present investigation was conducted to study the contributive role of clinical and subclinical hypothyroidism in causing dyslipidemia. A total of 220 clinical hypothyroidism patients, 146 subclinical hypothyroids and 200 euthyroid controls, with a mean age of 39 years (range- 25 - 55 years)...

  • Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. Badellino, Karen O; Wolfe, Megan L; Reilly, Muredach P; Rader, Daniel J // PLoS Medicine;Feb2006, Vol. 3 Issue 2, pe22 

    Background: Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models. We hypothesized that EL concentrations would be associated with decreased HDL-C and increased...

  • Serum Fas/FasL levels in dependence on clinical presentations of coronary disease and their relationship with risk factors. Ristić, Tatjana; Djordjević, Vidosava B.; Deljanin-Ilić, Marina; Ćosić, Vladan; Kundalić, Slavica // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Jul2010, Vol. 67 Issue 7, p537 

    Background/Aim. Ischemic heart disease is mostly a consequence of atherosclerosis. Besides the inflammation, the Fas/Fas ligand (FasL)/caspase death pathway is documented to be activated in atherosclerotic lesions. The aim of this study was to compare the values of soluble forms of Fas and FasL...

  • IMB2026791, a Xanthone, Stimulates Cholesterol Efflux by Increasing the Binding of Apolipoprotein A-I to ATP-Binding Cassette Transporter A1. Jikai Liu; Zhongbing Zhang; Yanni Xu; Tingting Feng; Wei Jiang; Zhuorong Li; Bin Hong; Zijian Xie; Shuyi Si // Molecules;Mar2012, Vol. 17 Issue 3, p2833 

    It is known that the ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. Several laboratories have demonstrated that ABCA1 binding to lipid-poor apolipoprotein A-I (apoA-I) will mediate the assembly of nascent...

  • Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease. Xiao-min Bu; Dong-mei Niu; Jia Wu; Yun-long Yuan; Jia-xi Song; Jun-jun Wang // Lipids in Health & Disease;1/10/2017, Vol. 16, p1 

    Background: Preβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients...

  • Differences and associations of metabolic and vitamin D status among patients with and without sub-clinical hypothyroid dysfunction. Aljohani, Naji J.; Al-Daghri, Nasser M.; Al-Attas, Omar S.; Alokail, Majed S.; Alkhrafy, Khalid M.; Al-Othman, Abdulaziz; Yakout, Sobhy; Alkabba, Abdulaziz F.; Al-Ghamdi, Ahmed S.; Almalki, Mussa; Mahmood Buhary, Badurudeen; Sabico, Shaun // BMC Endocrine Disorders;2013, Vol. 13 Issue 1, p31 

    Background: Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of the population suffer from hypovitaminosis D (<50 nmol/l). In this...

  • Tea consumption is inversely associated with weight status and other markers for metabolic syndrome in US adults. Vernarelli, Jacqueline; Lambert, Joshua // European Journal of Nutrition;Apr2013, Vol. 52 Issue 3, p1039 

    Purpose: Tea ( Camellia sinensis) is a widely consumed beverage, and laboratory and some intervention studies have indicated the potential health benefits of hot tea. The present study examines the association between tea consumption (evaluating hot and iced tea independently) and markers for...

  • Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease. Agarwal, Rachna; Talwar, Puneet; Kushwaha, Suman S.; Tripathi, Chandra Bhushan; Kukreti, Ritushree // Annals of Indian Academy of Neurology;Jul-Sep2015, Vol. 18 Issue 3, p320 

    Background: Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics