Long-term Clinical Follow-up, without Antiretroviral Therapy, of Patients with Chronic HIV-1 Infection with Good Virological Response to Structured Treatment Interruption

Florence, Eric; García, Felipe; Plana, Montserrat; Fumero, Emilio; Castro, Pedro; Lopez, Anna; Cruceta, Anna; Gil, Cristina; Arnedo, Mireia; Miró, José M.; Pumarola, Tomás; Gallart, Teresa; Gatell, José M.
August 2004
Clinical Infectious Diseases;8/15/2004, Vol. 39 Issue 4, p569
Academic Journal
The present study assessed the long-term clinical follow-up of 26 of 60 human immunodeficiency virus (HIV)- positive patients who followed structured treatment interruption (STI) protocols and who, because of good virological response, did not resume receipt of highly active antiretroviral therapy (HAART)∅ The plasma viral load (pVL) noted after ⩾2 years without antiretroviral therapy remained significantly lower than the pVL noted before initiation of HAART, for 11 of the 26 patients (i.e., for 18% of the 60 patients who had STI performed). The CD4+ T cell count remained stable throughout the study. A low pVL at the end of followup was independently associated with a low CD8+CD38+ T lymphocyte count and a high stimulation index to p24 antigen after STI. In conclusion, ∼2 years after STI, only a low proportion of patients who had a good immunological profile at the end of the STI period still had a good virological response.


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