Nontuberculous Mycobacterial Infection in Children: A 2-Year Prospective Surveillance Study in The Netherlands

Haverkamp, Margie H.; Arend, Sandra M.; Lindeboom, Jerome A.; Hartwig, Nico G.; van Dissel, Jaap T.
August 2004
Clinical Infectious Diseases;8/15/2004, Vol. 39 Issue 4, p450
Academic Journal
We performed a prospective, 2-year nationwide study to assess incidence and disease characteristics of suspected infections with nontuberculous mycobacteria (NTM) in children, via the Netherlands Pediatric Surveillance Unit. Data for 61 children were reported (median age, 31 months; interquartile range, 22-50 months; female sex, 37 subjects); 2 subjects had an underlying disease. Most children (53 [87%} of 61) had cervical lymph node enlargement, with abscess in 25 (47%) and fistula in 11 (21%). The estimated annual incidence of NTM infection was 77 cases per 100,000 children. In 16 children, the diagnosis was based solely on the results of skin tests with mycobacterial antigens. Cultures were performed in 36 cases and yielded mycobacteria in 27 (75%); Mycobacterium avium was isolated from 18 cultures. Children with a culture positive for mycobacteria did not differ in presentation, complications, or treatment from those whose cultures showed no growth. Thirty children underwent surgery, and chemotherapy was the single treatment in 24 (39%) of the cases. The treatment of localized NTM infection in immunocompetent children by antimycobacterial drugs should be evaluated further.


Related Articles

  • The Bacteriologic Yield in Children with Intrathoracic Tuberculosis. Marais, B. J.; Hesseling, A. C.; Gie, R. P.; Schaaf, H. S.; Enarson, D. A.; Beyers, N. // Clinical Infectious Diseases;4/15/2006, Vol. 42 Issue 8, pe69 

    This report documents the bacteriologic yield in children who received treatment for intrathoracic tuberculosis in an area where it is highly endemic. A total of 307 children were included in the study, and bacteriologic confirmation was achieved in 122 (62.2%) of 196 children from whom...

  • Bovine Tuberculosis at the Wildlife-Livestock-Human Interface in Hamer Woreda, South Omo, Southern Ethiopia. Tschopp, Rea; Aseffa, Abraham; Schelling, Esther; Berg, Stefan; Hailu, Elena; Gadisa, Endalamaw; Habtamu, Meseret; Argaw, Kifle; Zinsstag, Jakob // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Bovine tuberculosis (BTB) is endemic in cattle in the Ethiopian Highlands but no studies have been done so far in pastoralists in South Omo. This study assessed the prevalence of bovine tuberculosis (BTB) at an intensive interface of livestock, wildlife and pastoralists in Hamer Woreda (South...

  • How To Diagnose Mycobacterial Infections in Children. Chavalittamrong, Burana // Clinical Pediatrics;May1973, Vol. 12 Issue 5, p277 

    Presents the method on how to diagnose mycobacterial infections in children. Features of the tuberculin tine test; Reliability of Tuberculin Purified Protein Derivative diagnostic antigen; List of common atypical mycobacterial antigens.

  • Chest wall tuberculosis: a review of CT appearances. Morris B S; Maheshwari M; Chalwa A // British Journal of Radiology;May2004, Vol. 77 Issue 917, p449 

    Tuberculous abscesses of the chest wall, though uncommon are not infrequently encountered in countries endemic to the disease. This pictorial review of 14 patients highlights the varied appearance of tuberculosis (TB) of the chest wall on CT. The patients ranged in age from 9 to 55 years (a mean...

  • Misindentification of Mycobacterium kumamotonense as M. tuberculosis. Rodriguez-Aranda, Almudena; Jiménez, Maria S.; Yubero, Jesús; Chaves, Fernando; Rubio-Garcia, Rafael; Palenque, Elia; Garcia, Maria J.; Menéndez, M. Carmen // Emerging Infectious Diseases;Jul2010, Vol. 16 Issue 7, p1178 

    The article describes a case of misindentification of Mycobacterium (M.) kumamotonense as M. tuberculosis acquired from a cervical lymph node of a 30-year-old man in Madrid, Spain. The biopsy specimen obtained from the patient showed necrotizing granulomatous lymphadenopathy. The clinical...

  • Case Report: An Unusual Presentation of Kawasaki Disease. Jenkins, Patricia F.; O'Neal, Theresa // American Orthoptic Journal;1999, Vol. 49, p191 

    Presents a case study of a child with Kawasaki disease who presented with a nerve palsy secondary to increased intercranial pressure. Characteristics of the disease; Background on the patient; Analysis of the case.

  • Kawasaki disease. Curtis, Nigel // BMJ: British Medical Journal (International Edition);08/09/97, Vol. 315 Issue 7104, p322 

    Editorial. Discusses diagnosis and treatment options for Kawasaki disease. Causes and symptoms of the disease common in children under five years old; Difficulty in diagnosis; Similarity of the disease with other childhood diseases; Uncertainty about the use of immunoglobulin.

  • Kawasaki Disease: A Maturational Defect in Immune Responsiveness. Kuijpers, T. W.; Wiegman, A.; van Lier, R. A. W.; Roos, M. T. L.; Wetheim-van Dillen, P. M. E.; Pinedo, S.; Ottemkamp, J. // Journal of Infectious Diseases;12/1/99, Vol. 180 Issue 6, p1869 

    Kawasaki disease (KD), an acute febrile disease in children of unknown etiology, is characterized by a vasculitis that may result in coronary artery aneurysms (CAAs). In new patients with KD, a selective and prolonged T cell unresponsiveness to activation via the T cell antigen receptor CD3 was...

  • Filipino children at elevated risk for blood vessel inflammation associated with Kawasaki disease. Shulman, Stanford T. // Infectious Diseases in Children;Jun2011, Vol. 24 Issue 6, p9 

    The article discusses a research study on the higher risk of Filipino children with Kawasaki disease (KD) for inflammation of blood vessel based on the analysis of 345 patients in San Diego County where 24% of Filipino children with KD have aneurysms as against 10.5% in children of other Asian...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics