Maternal ethnicity and risk of neural tube defects: a population-based study

Ray, Joel G.; Vermeulen, Marian J.; Meier, Chris; Cole, David E. C.; Wyatt, Philip R.
August 2004
CMAJ: Canadian Medical Association Journal;8/17/2004, Vol. 171 Issue 4, p343
Academic Journal
Background: Maternal body mass and the presence of diabetes mellitus are probable risk factors for neural tube defects (NTDs). The association between maternal ethnicity and the risk of NTDs remains poorly understood, however. Methods: We performed a retrospective population-based study and included all women in Ontario who underwent antenatal maternal screening (MSS) at 15 to 20 weeks' gestation between 1994 and late 2000. Self-declared maternal date of birth, ethnicity and weight and the presence of pregestational diabetes mellitus were recorded in a standardized fashion on the MSS requisition sheet. NTDs were detected antenatally by ultrasonography or fetal autopsy and postnatally by considering all live and stillborn affected infants beyond 20 weeks' gestation. The risk of open NTD was evaluated across the 5 broad ethnic groups used for MSS, with white ethnicity as the referent. Results: Compared with white women ( n = 290 799), women of First Nations origin ( n = 1551) were at increased associated risk of an NTD-affected pregnancy (adjusted odds ratio [OR] 5.2, 95% confidence interval ([CI] 2.1-12.9). Women of other ethnic origins were not at increased associated risk compared with white women (women of Asian origin [ n = 75 590]: adjusted OR 0.9, 95% CI 0.6-1.3; black women [ n = 25 966]: adjusted OR 0.6, 95% CI 0.3-1.1; women of "other" ethnic origin [ n= 10 009]: adjusted OR 0.1, 95% CI 0.02-0.9). Interpretation: The associated risk of NTD-affected pregnancies was higher among women of First Nations origin than among women of other ethnic origins. The mechanisms for this discrepancy should be explored.


Related Articles

  • MRI of the fetal spine. Simon, Erin M. // Pediatric Radiology;Sep2004, Vol. 34 Issue 9, p712 

    Magnetic resonance imaging of the fetal spine is a vital complement to fetal sonographic examination. Assessing the wide spectrum of spinal dysraphism, as well as spinal neoplasia, allows for more correct prenatal diagnoses, patient care planning, and patient counselling. Proper appraisal of the...

  • Maternal Dietary Glycemic Intake and the Risk of Neural Tube Defects. Yazdy, Mahsa M.; Liu, Simin; Mitchell, Allen A.; Werler, Martha M. // American Journal of Epidemiology;Feb2010, Vol. 171 Issue 4, p407 

    Both maternal diabetes and obesity have been associated with an increased risk of neural tube defects (NTD), possibly due to a sustained state of hyperglycemia and/or hyperinsulinemia. Data were collected in the Boston University Slone Birth Defects Study (a case-control study) from 1988 to...

  • Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects T.I. Chang et al.: Oxidant regulation of neural tube gene expression. Chang, T. I.; Horal, M.; Jain, S. K.; Wang, F.; Patel, R.; Loeken, M. R. // Diabetologia;Apr2003, Vol. 46 Issue 4, p538 

    Aims/hypothesis. Maternal diabetes increases oxidative stress in embryos. Maternal diabetes also inhibits expression of embryonic genes, most notably, Pax-3, which is required for neural tube closure. Here we tested the hypothesis that oxidative stress inhibits expression of Pax-3, thereby...

  • The Neural Tube Defect: Issues of Prenatal Diagnosis, Genetic Counselling, Prevention and Management. Acharya, Ganesh; Jonsrud, Christoffer; Maltau, Jan Martin // Ultrasound;2006, Vol. 14 Issue 2, p95 

    Neural tube defects (NTDs) are among the most common major congenital abnormalities with a prevalence rate of approximately 1 per 1000 births, although it varies significantly according to geographical location. NTDs represent the first congenital malformations shown to be preventable through...

  • Prevalence of neural tube defects in South Australia, 1966-91: effectiveness and impact of prenatal diagnosis. Chan, Annabelle; Robertson, Evelyn F.; Haan, Eric A.; Keanne, Rosemary J.; Ranieri, Enzo; Carney, Annabel // BMJ: British Medical Journal (International Edition);9/18/93, Vol. 307 Issue 6906, p703 

    Investigates the prevalence of neural tube defects in South Australia. Examination on the effectiveness of prenatal screening for the defects; Stability of the total prevalence of the disease; Decline of prenatal diagnosis and termination of pregnancy in birth prevalence. INSET: Public health...

  • Alpha-Fetoprotein and the Prenatal Detection of Neural Tube Defects. Milunsky, Aubrey // American Journal of Public Health;Jun79, Vol. 69 Issue 6, p552 

    The article discusses the alpha-fetoprotein (AFP) and prenatal detection of defects on neural tube in the U.S. The alpha-fetoprotein is accepted as an essential tool for the early detection of open neural tube defects. There are reasons regarding how the AFP test may be used and monitored like...

  • Birth Weight and Parental BMI Predict Overweight in Children From Mothers With Gestational Diabetes. Schaefer-Graf, Ute M.; Pawliczak, Julia; Passow, Doerte; Hartmann, Reinhard; Rossi, Rainer; Bührer, Christoph; Harder, Thomas; Plagemann, Andreas; Vetter, Klaus; Kordonouri, Olga // Diabetes Care;Jul2005, Vol. 28 Issue 7, p1745 

    OBJECTIVE -- To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association with antenatal maternal, fetal, and recent anthropometric parameters of mother and father. RESEARCH DESIGN AND METHODS -- In 324 pregnancies of Caucasian women with...

  • The effects of gestational diabetes mellitus screening and diagnostic tests on fetal macrosomia. Keskin, Uğur; Mutlu Ercan, Cihangir; Güngör, Saadettin; Emre Karaşahin, Kazım; Ergün, Ali; Öztürk, Mustafa; Öztürk, Özlem // Perinatal Journal / Perinatoloji Dergisi;Dec2013, Vol. 21 Issue 3, p133 

    Objective: To assign the detection rate of the clinical gestational diabetes mellitus by using American Diabetes Association criteria, and to compare the results of the 50 g glucose challenge test (GCT) and 100 g oral glucose tolerance test (OGTT) with fetal macrosomia. Methods: The results of...

  • The analysis of amniocentesis results of pregnants who are at 16-22 weeks of gestation and undergone genetic amniocentesis. Timur, Alev; Uyar, İbrahim; Gülhan, İbrahim; Tan Saz, Nagehan; İleri, Alper; Özeren, Mehmet // Perinatal Journal / Perinatoloji Dergisi;Dec2013, Vol. 21 Issue 3, p101 

    Objective: It is aimed to evaluate the chromosome analysis results of cases who undergone genetic amniocentesis for prenatal diagnosis. Methods: Amniocentesis indications, culture successes, karyotype results, screening ultrasounds and gestational prognoses of 311 amniocentesis cases referred to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics