SARS vaccine undergoing animal testing

Tamburri, Rosanna
August 2004
CMAJ: Canadian Medical Association Journal;8/17/2004, Vol. 171 Issue 4, p320
Academic Journal
Deals with the two potential Severe Acute Respiratory Syndrome (SARS) vaccines developed by Canadian researchers. Results of the testing of the vaccines in mice and ferrets; Amount of time needed in developing a market-ready vaccine.


Related Articles

  • Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model. Cameron, Mark J.; Kelvin, Alyson A.; Leon, Alberto J.; Cameron, Cheryl M.; Ran, Longsi; Luoling Xu; Yong-Kyu Chu; Danesh, Ali; Yuan Fang; Qianjun Li; Anderson, Austin; Couch, Ronald C.; Paquette, Stephane G.; Fomukong, Ndingsa G.; Kistner, Otfried; Lauchart, Manfred; Rowe, Thomas; Harrod, Kevin S.; Jonsson, Colleen B.; Kelvin, David J. // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    In terms of its highly pathogenic nature, there remains a significant need to further define the immune pathology of SARS- coronavirus (SARS-CoV) infection, as well as identify correlates of immunity to help develop vaccines for severe coronaviral infections. Here we use a SARS-CoV...

  • Inactivated SARS-CoV Vaccine Prepared from Whole Virus Induces a High Level of Neutralizing Antibodies in BALB/c Mice. Lin Tang; Qingyu Zhu; Ede Qin; Man Yu; Zhifen Ding; Huiying Shi; Xiaojie Cheng; Caiping Wang; Guohui Chang; Qiang Zhu; Fang Fang; Haiyan Chang; Shuangli Li; Xumin Zhang; Xishu Chen; Jun Yu; Jian Wang; Ze Chen // DNA & Cell Biology;Jun2004, Vol. 23 Issue 6, p391 

    We tested the ability of inactivated SARS-CoV vaccine to induce neutralizing antibodies in BALB/c mice. The inactivated vaccine was prepared by SARS-CoV virus propagation in Vero cells, with subsequent �-propiolactone inactivation and Sepharose 4FF column chromatography purification. One...

  • Cross-Protectiveness and Immunogenicity of Influenza A/Duck/Singapore/3/97(H5) Vaccines against Infection with A/Vietnam/1203/04(H5N1) Virus in Ferrets. Lipatov, Aleksandr S.; Hoffmann, Erich; Salomon, Rachelle; Hui-Ling Yen; Webster, Robert G. // Journal of Infectious Diseases;10/15/2006, Vol. 194 Issue 8, p1040 

    Ferrets were immunized with two 7-µg doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1)(Viet/1203/04). Serum samples did not react with Viet/1203/04 in...

  • Immunology: TB vaccine with a long view.  // Nature;1/27/2011, Vol. 469 Issue 7331, p446 

    The article presents a study by Claus Aagaard and colleagues which examines the effectiveness of H56 vaccine containing three antigens such as Rv2260c for the treatment of tuberculosis (TB) infection in mice.

  • Optimization of a DNA Vaccine Against SARS. Zakhartchouk, Alexander N.; Viswanathan, Sathiyanarayanan; Moshynskyy, Igor; Petric, Martin; Babiuk, Lorne A. // DNA & Cell Biology;Oct2007, Vol. 26 Issue 10, p721 

    Severe acute respiratory syndrome coronavirus (SARS-CoV) first appeared in Southern China in November 2002, and then quickly spread to 33 countries on five continents along international air travel routes. Although the SARS epidemic has been contained, there is a clear need for a safe and...

  • A Heterologous Prime-Boost Vaccination Regimen Using ORFF DNA and Recombinant ORFF Protein Confers Protective Immunity against Experimental Visceral Leishmaniasis. Tewary, Poonam; Jam, Manju; Sahani, Mayurbhai H.; Saxena, Shailendra; Madhubala, Rentala // Journal of Infectious Diseases;6/15/2005, Vol. 191 Issue 12, p2130 

    Objective. We describe the effectiveness of a prime-boost vaccination regimen using the open-reading frame (ORFF) gene from the LD1 locus of Leishmania donovani. Methods. A group of BALB/c mice was immunized with the plasmid carrying the gene for ORFF (F/pcDNA 3.1) and given a booster dose of...

  • Experimental Infection of Mice with Avian Paramyxovirus Serotypes 1 to 9. Khattar, Sunil K.; Kumar, Sachin; Xiao, Sa; Collins, Peter L.; Samal, Siba K. // PLoS ONE;2011, Vol. 6 Issue 2, p1 

    The nine serotypes of avian paramyxoviruses (APMVs) are frequently isolated from domestic and wild birds worldwide. APMV-1, also called Newcastle disease virus, was shown to be attenuated in non-avian species and is being developed as a potential vector for human vaccines. In the present study,...

  • PERTACTIN ENHANCES THE IMMUNOGENICITY OF THE PERTUSSIS TOXIN AND FILAMENTOUS HEMAGGLUTININ IN ACELLULAR VACCINES. El-kady, E. M.; Osman, M.; Mostafa, A. A.; Ibrahim, N. M.; Wahby, A. F. // International Journal of Academic Research;Jan2010, Vol. 2 Issue 1, p124 

    Four combinations of Bordetella pertussis (B. pertussis) antigens were supplemented with extra pertactin (PRN) and evaluated for specific immune response in mice. The immunogens were prepared by fractionation of the concentrated broth of the vaccine strain 134 on a Sephacryl-300 column. The...

  • Genetic Immunization with CDR3-Based Fusion Vaccine Confers Protection and Long-Term Tumor-Free Survival in a Mouse Model of Lymphoma. Iurescia, Sandra; Fioretti, Daniela; Pierimarchi, Pasquale; Signori, Emanuela; Zonfrillo, Manuela; Tonon, Giancarlo; Fazio, Vito M.; Rinaldi, Monica // Journal of Biomedicine & Biotechnology;2010, p1 

    Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-cell malignancies. We have previously shown that CDR3-based DNA immunization can induce immune response against lymphoma and explored this strategy to provide protection in a murine B-cell lymphoma model....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics