TITLE

A new computer model of mitral valve hemodynamics during ventricular filling

AUTHOR(S)
Szabó, Gábor; Soans, Davis; Graf, Andy; J. Beller, Carsten; Waite, Lee; Hagl, Siegfried
PUB. DATE
August 2004
SOURCE
European Journal of Cardio-Thoracic Surgery;Aug2004, Vol. 26 Issue 2, p239
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Quantitative description of left ventricular diastolic filling and mitral valve function remains difficult despite advances in echocardiography. The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement. Methods: Six animals were instrumented with aortic flow meter, left atrial pressure catheter and combined left ventricular pressure–conductance catheter. The model simulates ventricular and arterial pressures and flows during diastolic filling. Input parameters include maximum mitral valve area, blood viscosity and density, atrial compliance, left ventricular active relaxation characteristics and initial pressure and flow values. The outputs of the model are atrial and ventricular pressure as well as transmitral flow as a function of time. The model primarily consists of a system of four first-order, non-linear ordinary differential equations which were solved with MATLAB software. Results: Left atrial and ventricular pressure data and model flow curves were nearly identical under baseline conditions, during rapid preload reduction by vena caval occlusion and after prosthetic valve replacement. Measured and model based calculation of early diastolic filling volume (E-wave), showed an excellent correlation under all three conditions (r=0.998, P<0.0001; r=0.997, P<0.0001; r=0.974, P<0.0001, respectively) with a mean difference less then two percent. Conclusion: The new lumped parameter model of left ventricular filling allows for the first time a detailed simulation of pressure and flow curves in the left heart including transmitral hemodynamics.
ACCESSION #
14036731

 

Related Articles

  • Diastolic gradient of pressure and the effective artificial mitral valve section area in terms of its dysfunction. Byakin, S.; Tirkin, G.; Ipatenko, V.; Fedoseikin, I.; Shumkin, V.; Balashkina, E.; Lyanguzova, M. // Human Physiology;Jan2012, Vol. 38 Issue 1, p116 

    A seven-year experience of treatment of 126 patients with mitral heart disease who were implanted monocuspid MIKS and bicuspid MEDINZh-2 and ROSKARDIKS prostheses (Russia) is presented. The comparative assessment of hemodynamic efficiency and the analysis of the rate of the occurrence of...

  • Echocardiographic and Hemodynamic Correlated in Prinzmetal Angina Pectoris: A Case Report. Guazzi, Maurizio D.; Polese, Alvise; Magrini, Fabio; Olivari, Maria T.; Moruzzi, Paolo; Fiorentini, Cesare // Angiology;Oct1979, Vol. 30 Issue 10, p708 

    In a patient suffering from Prinzmetal angina pectoris, ischemic attacks of the anterior left ventricular wall were associated with the following changes: fall in cardiac output: increased left ventricular diastolic pressure (LVDP) and volume; flattening of the septal motion; marked reduction of...

  • Mitral Valve Replacement After 14 Years Of Closed Mitral Commissurotomy. �zbek, Cengiz; Yetkin, Ufuk; �zpak, Berkan; Sahin, Aykut; G�ktogan, Tayfun; G�rb�z, Ali // Internet Journal of Thoracic & Cardiovascular Surgery;2008, Vol. 11 Issue 2, p19 

    Mitral stenosis is the most frequently encountered valvular pathology and may require surgical intervention when the lesion is severe in rheumatic etiology. Closed mitral comissurotomy (CMC) was the first effective intervention in valvular heart disease. CMC provides excellent long-term...

  • Acute effect of percutaneous MitraClip therapy in patients with haemodynamic decompensation. Biner, Simon; Siegel, Robert J.; Feldman, Ted; Rafique, Asim M.; Trento, Alfredo; Whitlow, Patrick; Rogers, Jason; Moon, Marc; Lindman, Brian; Zajarias, Alan; Glower, Donald; Kar, Saibal // European Journal of Heart Failure;Aug2012, Vol. 14 Issue 8, p939 

    Aims To evaluate the haemodynamic effect of acute procedural success (APS) after MitraClip therapy in patients with haemodynamic decompensation. Methods and results Of 107 patients, 79 achieved APS after MitraClip implantation. The increase in cardiac index (CI) was primarily detected in...

  • Persistent pulmonary artery hypertension in patients undergoing balloon mitral valvotomy. Mohanan Nair, Krishna Kumar; Sivadasan Pillai, Harikrishnan; Titus, Thomas; Varaparambil, Ajitkumar; Sivasankaran, Sivasubramonian; Mahadevan Krishnamoorthy, Kavassery; Namboodiri, Narayanan; Sasidharan, Bijulal; Thajudeen, Anees; Ganapathy, Sanjay; Tharakan, Jaganmohan // Pulmonary Circulation;Apr-Jun2013, Vol. 3 Issue 2, p426 

    Pulmonary artery pressure (PAP) is known to regress after successful balloon mitral valvotomy (BMV). Data of persistent pulmonary artery hypertension (PPAH) following BMV is scarce. We analyzed the clinical, echocardiographic, and hemodynamic data of 701 consecutive patients who have undergone...

  • Ablación septal con alcohol para tratar miocardiopatía hipertrófica. López-Aburto, Gustavo; Palacios-Rodríguez, Juan Manuel; Cantú-Ramírez, Samuel; Galván-García, Eduardo; Tolosa-Dzul, Gonzalo; Morán-Benavente, Armando; Ontiveros-Martínez, Raúl // Revista Medica del IMSS;jul-ago2013, Vol. 51 Issue 4, p396 

    Objective: to know the clinical and hemodynamic course in septal obstructive hypertrophic cardiomyopathy (SOHC) after alcohol ablation. Methods: observational, longitudinal study, including 21 patients with SOHC was done with functional class of the New York Heart Association (CF-NYHA)...

  • Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease. Ling Sun; Chandra, Santanu; Sucosky, Philippe // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    The bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly and is frequently associated with calcific aortic valve disease (CAVD). The most prevalent type-I morphology, which results from left-/right-coronary cusp fusion, generates different hemodynamics than a tricuspid...

  • Prognostic significance of mitral regurgitation after myocardial infarction: An echocardiography-based study. Kumar, Anil; Mahesh, N.K. // Medical Journal of Dr. D.Y. Patil University;Sep/Oct2016, Vol. 9 Issue 5, p615 

    The author discusses the prognostic significance of mitral regurgitation (MR) after myocardial infarction (MI). The author states that MR has been a frequent complication during and after acute phase of MI. The author notes that MR exhibits range of severity such as hemodynamically obvious to...

  • Severe mitral valve regurgitation due to a large ring dehiscence in ischaemic cardiomyopathy. Sanchez, Eladio; Cid-Cumplido, Manuela; Tarhini, Ibrahim Said; Gonzalez, Jose Ramon // European Journal of Cardio-Thoracic Surgery;Feb2013, Vol. 43 Issue 2, p444 

    The article offers brief information on a patient with a history of coronary artery disease and currently having the heart disorder severe mitral regurgitation.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics